Our immune system keeps us healthy by fighting off bacteria, viruses, and other pathogens that cause infection and disease. Inflammation is the immune system’s response to a problem such as a germ or physical injury. Inflammation may be experienced as redness, swelling, or pain. 

In certain cases, the immune system mistakenly targets a part of the body that it believes is harmful. The mistaken immune response commonly results in inflammation and damage to healthy tissues. This is known as an autoimmune disease. 

An example of an autoimmune disease is rheumatoid arthritis (RA). RA occurs when the immune system attacks the lining of the joints, causing painful swelling. Over a long period of time, inflammation from RA can cause joint and bone damage. 

We continue to develop new treatments to control inflammation and autoimmune conditions, in the hopes of reducing the toll that they take on people’s lives. Clinical trials are an important part of this effort. We invite you to explore our clinical trials in inflammation and immunology below. 

Explore our clinical trials in inflammation and immunology


Select from the list below to view Pfizer clinical trials that are looking for participants. If you do not find what you are looking for, try using the search box below.

Arthritis: Rheumatoid, Psoriatic, Juvenile idiopathic

Atopic dermatitis (Eczema)

Crohn’s disease


Ulcerative colitis


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      Frequently asked questions

      What are autoimmune diseases?

      The immune system plays an important role in protecting your body from bacteria, viruses, and other things that could make you sick. The immune system is usually pretty good at defending the body from infections and other unwanted changes. However, in some people, the immune system mistakenly attacks healthy parts of the body. The mistaken attacks may be against specific cells, tissues, and organs, causing damage that can sometimes become life-threatening. This is known as an autoimmune disorder.

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      What is inflammation and why is it important?

      Inflammation is the immune system’s response to a problem such as a germ or physical injury. Inflammation may be experienced as redness, swelling, or pain. Without inflammation, wounds would have trouble healing and infections could become worse.

      However, if the inflammation is chronic (continuing for too long), it could begin damaging healthy cells, tissues, and organs. This can lead to serious conditions such as joint damage and cardiovascular diseases.

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      What happens in a clinical trial?

      What happens in a clinical trial depends on the ‘protocol.’ A protocol is a detailed plan that explains the purpose of the clinical trial and how it will be run. If you consider joining a clinical trial, these details will be explained to you as part of the informed consent process. They include: 

      • the length of the clinical trial 
      • the study medicines, procedures, and tests in the clinical trial
      • the schedule of study activities 
      • information about who can participate 
      • how side effects will be tracked, managed, and reported 
      • the rules that must be followed 

      A clinical trial may also have aspects such as randomization, placebo, or blinding.  

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      Who can join a clinical trial?

      We encourage everybody to consider joining clinical trials. There are many types of clinical trials that study different aspects of health in people with a variety of backgrounds and conditions. Each clinical trial has its own criteria for who may participate. These are called eligibility criteria.  
      Eligibility criteria include things like your age, sex, overall health, type of condition, and your medical treatment history. As part of the steps to join a clinical trial, the study doctor will confirm whether you meet all eligibility criteria and are able to participate.

      Participation in a clinical trial is always voluntary. The decision to join is personal, and it is yours.

      To learn more about Pfizer’s clinical trials, visit Our Research or search for trials here.

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      Who can I contact regarding Pfizer clinical trials?

      We list all of our clinical trials that are recruiting participants or plan to recruit shortly in our Find a Trial search engine. We welcome you to explore our clinical trials and the information provided about each study. There is contact information available on each study’s webpage. 
      For general inquiries about Pfizer clinical trials, you may call 1-800-887-7002 or email [email protected].

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      What if I can’t find a clinical trial that’s right for me on this website?

      Our Find a Trial search engine only provides information about Pfizer clinical trials. To search for all registered clinical trials, regardless of the study sponsor, you may visit ClinicalTrials.gov.

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      Learn about the different people who make clinical trials happen

      Seeking more options for people with inflammatory and autoimmune conditions

      Clinical trial participant
      Clinical trial participant

      Seeking more options for people with inflammatory and autoimmune conditions

      At Pfizer, we’re committed to developing new treatments for autoimmune and inflammatory disorders so that people living with these conditions can have more options. As part of this effort, we’re looking for better ways to treat the root causes of these conditions. We’re developing new treatments that we believe target key proteins and pathways in the body.

      Learn more on Pfizer.com
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