NCT05675449
A clinical trial to learn about the effects of combined treatments for multiple myeloma that has returned or not responded to previous treatment
The MagnetisMM-20 study is looking for around 12 people with multiple myeloma that has returned or not responded to previous treatment.
The study is exploring the effects of an investigational combination of treatments given in addition to regular medical care, and whether it can help people with multiple myeloma.
Who may participate
Each clinical study has its own guidelines for who can participate, called eligibility criteria. However, only the research study staff can determine if you qualify to enroll in the study.
What to expect
1 call or visit at least every month
Some studies require the study team to stay in contact with the participant for a period of time after the participant completes the main part of the study. This long-term follow up is to collect additional information on the study drug over time.
About the study treatments
About the study treatments
We are exploring whether a combination of treatments is safe and effective for people with multiple myeloma. The study treatments are given as a subcutaneous injection, an intravenous infusion, or as a tablet taken by mouth. Study treatments given as a subcutaneous injection or as an infusion are administered by a trained medical professional.
About the study treatments
Potential benefits and risks of taking part in this study
Potential benefits and risks of taking part in this study
People who take part in clinical studies are key to advancing medical research. By taking part in the MagnetisMM-20 study, you will be aiding medical research which may help others with multiple myeloma in the future.
Over the course of the study, a participant’s health may get better, get worse, or stay the same. People who are considering taking part in the study will be given a complete list of risks and possible discomforts before agreeing to participate. As with any medication, there may be a reaction to the study treatments.
Potential benefits and risks of taking part in this study
Frequently asked questions
What is multiple myeloma?
Multiple myeloma is a type of blood cancer that forms in bone marrow. Healthy bone marrow produces plasma cells, which make antibodies to fight infection. But in multiple myeloma, plasma cells become cancerous. These cancer cells can crowd out normal blood cells, forming tumors and leaving a person vulnerable to infection.
How does this study medicine work?
Elranatamab is thought to work by connecting certain immune system cells, known as T-cells, to myeloma cells (cancer cells). Connecting these cells activates the immune cells, potentially killing the myeloma cells.
Carfilzomib is known to block actions of certain proteins which can kill the myeloma cells.
Dexamethasone is used in the treatment of multiple myeloma as an anti-inflammatory to reduce the number of white-blood cells moving to the myeloma cells, it can also potentially kill the myeloma cells.
What is Informed Consent?
Informed consent is one of the most important tools to help you understand how your rights, safety, and well-being will be addressed throughout the study .
During the informed consent discussion, you will be given all details about the study, including potential benefits and risks of taking part. You will also be given a document summarizing this information, which you will sign to confirm that you would like to take part in the clinical trial.
Is taking part in this clinical trial voluntary?
Yes, participation in clinical trials is completely voluntary: taking part in a trial is your choice. You are free to stop being in this trial at any time and for any reason and it will not affect your future medical care in any way.
Why do we need clinical trials?
Clinical trials are important to understand more about potential treatment options for all sorts of conditions. Clinical research studies also help us learn more about the side effects of a potential treatment and to understand whether the possible benefits outweigh the risks.
Will I have to pay to be in the study? Will my insurance cover the cost?
The study treatments and all study-related care and procedures are provided at no cost. You don’t need health insurance to join a clinical study. However, you (or your health insurance provider) may be responsible for medical expenses that are part of your usual healthcare. Talk with your study team or review the informed consent document to find out exactly what is covered.
Is there travel support available for participants in this study?
Travel to the study center and other expenses (such as meals) may be covered. Please discuss the details with your study team and refer to the informed consent document for details on reimbursement and compensation.
Will my personal information be kept private?
Your health information and any data that could be used to identify you (such as immigration status) will be kept private and safe. Only information that relates to the study will be collected, and only your study team, study doctor, and organizations that oversee the study will be able to access it. Your personal information won’t be shared with third parties such as the government or advertisers.
