Breast Cancer
Clinical Trials

Every clinical trial has unique requirements for participation. These requirements are called eligibility criteria and may include things like the stage of your cancer, the type of breast cancer you have, and any treatment you received in the past.

When considering if a specific clinical trial is a good fit for you, a doctor evaluates:

• The stage of the breast cancer (1 through 4) at diagnosis, which tells them how big the tumor is and if the cancer has spread outside of the breast(s)
• The tumor grade score (1 to 3). Grade 1 cells look more like normal cells compared to Grade 3 cells
• Whether this is first-time cancer or cancer that has returned after prior therapy
• Your age, menopausal status, overall health, and treatment preferences

Other things a doctor may consider in evaluating whether a specific clinical trial is right for you:

• Hormone receptor status: Some breast cancer cells have estrogen and/or progesterone receptors on their surface and require the hormones estrogen and/or progesterone to grow. This is described as being hormone receptor-positive, or HR-positive breast cancer. If the cancer cells have only estrogen receptors on their surface and require estrogen to grow, this is described as being estrogen receptor-positive, or ER-positive breast cancer.
• Human epidermal growth factor receptor 2 (HER2) status: HER2 is another kind of receptor found on the surface of some breast cancer cells. When there are too many HER2 receptors, it is described as HER2-positive breast cancer and can lead to uncontrolled breast cell division and tumor formation.
• Triple-negative breast cancer (TNBC): Triple-negative breast cancer does not have any of the receptors commonly found in breast cancer, namely the receptors for estrogen, progesterone, or HER2.

People who take part in clinical trials are key to advancing medical research. By participating in a breast cancer clinical trial, you may contribute to finding the next breakthrough breast cancer treatment. This can potentially benefit your own treatment journey and also help other people with breast cancer in the future.

Your safety and privacy are the highest priority while participating in any of our clinical trials.

• Your participation in our clinical trials is voluntary, and you are free to withdraw at any time, for any reason.
• Your decision to stop being in a clinical trial will not affect your regular medical care or any benefits that you are entitled to.

If a Pfizer breast cancer clinical trial is a good fit for you and you decide to take part, you will receive:

• Close monitoring of your breast cancer during the trial
• Access to investigational medicines or standard of care treatment (which is the established treatment currently used in people with your breast cancer type)
• The study medicine and any study-related procedures provided at no cost (these are generally covered by the sponsor)
• Reimbursement for any reasonable expenses that you may have as a result of taking part in the study such as parking, meals, or other travel-related expenses (check with your study team as this may vary)
• The opportunity to help advance scientific knowledge of breast cancer and potentially help other people with breast cancer in the future