When it comes to your health, no one is a better advocate than you. That’s why it’s important that you understand your breast cancer and available options. In addition to FDA-approved treatments, there are potential medicines that are being researched in clinical trials, also called studies. 

We are committed to supporting people living with breast cancer by developing innovative medicines, providing educational resources, and helping to remove barriers to care. We have several study medicines in development that may have the potential to help people with various types of breast cancer. 

Together with the breast cancer community, meaningful change has been made for women and men living with breast cancer. But our work is far from finished. It is through the commitment of people like you that we can work to make progress against breast cancer. Thank you for taking the time to learn more. 

Featured Breast Cancer clinical trials

Recruiting
FourLight-3- for people recently diagnosed with HR-positive, HER2- negative advanced or metastatic breast cancer

A phase 3 clinical trial evaluating a CDK4 inhibitor plus letrozole

Learn more
Not yet recruiting
DV-006- for people with HER2-expressing advanced breast cancer that has worsened after prior treatment

A phase 1b/2 clinical trial evaluating disitamab vedotin

To see full list of all Pfizer Breast Cancer Clinical Trials, click here 

Participating in these clinical trials

Every clinical trial has unique requirements that determine who can participate, called eligibility criteria. To view our enrolling clinical trials and their eligibility criteria in more detail, please visit the study webpages.

Before you decide to participate in one of our clinical trials, the study doctor and their team will review the trial details with you including what you can expect to happen during the trial, the length of participation, and potential risks and benefits.

Age

18+ years

Sex

Female and Male

This information is a summary of the eligibility criteria across the clinical trials within breast cancer. Each clinical trial will have its own unique requirements for who may participate (eligibility criteria). To learn more about the requirements for a clinical trial that is actively recruiting, visit the study’s webpage above. Only the research study staff can determine if you qualify to enroll in the clinical trial.

Why participate in a clinical trial?

People who take part in clinical trials are key to advancing medical research. By participating in a breast cancer clinical trial, you may contribute to finding the next breakthrough breast cancer treatment. This can potentially benefit your own treatment journey and also help other people with breast cancer in the future.

Your safety and privacy are the highest priority while participating in any of our clinical trials.

  • Your participation in our clinical trials is voluntary, and you are free to withdraw at any time, for any reason.
  • Your decision to stop being in a clinical trial will not affect your regular medical care or any benefits that you are entitled to.

If a Pfizer breast cancer clinical trial is a good fit for you and you decide to take part, you will receive:

  • Close monitoring of your breast cancer during the trial
  • Access to investigational medicines or standard of care treatment (which is the established treatment currently used in people with your breast cancer type)
  • The study medicine and any study-related procedures provided at no cost (these are generally covered by the sponsor)
  • Reimbursement for any reasonable expenses that you may have as a result of taking part in the study such as parking, meals, or other travel-related expenses (check with your study team as this may vary)
  • The opportunity to help advance scientific knowledge of breast cancer and potentially help other people with breast cancer in the future

Why participate in a clinical trial?

Woman wearing glasses with a soft smile – Pfizer Clinical Trials
Woman wearing glasses with a soft smile – Pfizer Clinical Trials

Understanding common eligibility criteria in breast cancer clinical trials

Every clinical trial has unique requirements for participation. These requirements are called eligibility criteria and may include things like the stage of your cancer, the type of breast cancer you have, and any treatment you received in the past.

When considering if a specific clinical trial is a good fit for you, a doctor evaluates:

  • The stage of the breast cancer (1 through 4) at diagnosis, which tells them how big the tumor is and if the cancer has spread outside of the breast(s)
  • The tumor grade score (1 to 3). Grade 1 cells look more like normal cells compared to Grade 3 cells
  • Whether this is first-time cancer or cancer that has returned after prior therapy
  • Your age, menopausal status, overall health, and treatment preferences

Other things a doctor may consider in evaluating whether a specific clinical trial is right for you:

  • Hormone receptor status: Some breast cancer cells have estrogen and/or progesterone receptors on their surface and require the hormones estrogen and/or progesterone to grow. This is described as being hormone receptor-positive, or HR-positive breast cancer. If the cancer cells have only estrogen receptors on their surface and require estrogen to grow, this is described as being estrogen receptor-positive, or ER-positive breast cancer.
  • Human epidermal growth factor receptor 2 (HER2) status: HER2 is another kind of receptor found on the surface of some breast cancer cells. When there are too many HER2 receptors, it is described as HER2-positive breast cancer and can lead to uncontrolled breast cell division and tumor formation.
  • Triple-negative breast cancer (TNBC): Triple-negative breast cancer does not have any of the receptors commonly found in breast cancer, namely the receptors for estrogen, progesterone, or HER2.

Representation is key

A young child kissing a women’s cheek while embracing them from behind – Pfizer Clinical Trials
A young child kissing a women’s cheek while embracing them from behind – Pfizer Clinical Trials

Representation is key

Many factors controlled by genetics, including race, ethnicity, and gender, can impact how people respond to a medicine and/or vaccine. That is why it is so important that clinical trials include people of all backgrounds.

Choosing to participate is very personal and many factors may weigh in your decision-making. Historically, there have been unjust practices in clinical research and barriers to access that have stood in the way of inclusive participation. Today, many protections are in place to better protect participants’ rights and safety and ensure that clinical trials are conducted ethically.

If you choose to participate, you must provide your consent (permission) before joining a study and can decide to withdraw from the study at any time, for any reason.

Your participation in a clinical trial may help advance potential investigational medicines for people across the globe. When everyone is accurately represented, we can improve the development of novel study medicines, learn how they work for different people, and reduce health disparities among underrepresented populations.

Learn more about the clinical trial experience

Hear from the Women of When We Tri(al)
Hear from the Women of When We Tri(al)
Black women make up 3% of clinical trial participants. Meet women both diagnosed with breast cancer and those who work in clinical trials as they talk about things to consider and their experiences in breast cancer clinical trials.
Watch video
Karen Peterson’s Story
Karen’s Story
Karen, a stage 4 triple negative breast cancer survivor, shares her experience as a previous clinical trial participant.
Watch video
Deltra’s Story
Deltra’s Story
Deltra, as a metastatic breast cancer patient, talks about the importance of knowing your available treatment options.
Watch video
Tigerlily Foundation
Reducing Health Inequities for Black Women with Breast Cancer
People of color continue to be underrepresented in global clinical trials. Together, Pfizer, Inc. and the Tigerlily Foundation are helping to tackle barriers to equitable care for women of color and patient populations living with breast cancer.
Watch video
Science Will Win Season 2 Takes on Breast Cancer
Science Will Win: Clinical Trials: Bringing Research to Life
Adam Rutherford and guest break down the next steps in how potential breast cancer treatments move forward from the lab. What role do clinical trials play in the development of potential treatments? How are clinical trials developed? How can participants access clinical trials? And how are researchers and advocacy groups working to break down barriers in access to clinical trials?
Listen now
Science Will Win Season 2 Takes on Breast Cancer
Science Will Win: Breast Cancer: The Science, the Challenges, the Solutions
Oncologists have more innovative methods for treating breast cancer than ever before. Adam Rutherford and guests explore the hurdles and successes researchers face as they work to develop potential targeted therapies for breast cancer.
Listen now

Frequently asked questions

What is breast cancer?

Breast cancer is a type of cancer that starts in one or both breasts; cancer begins when cells start to grow out of control. Though it occurs mostly in women, men can get breast cancer. Each year about 2.3 million people are diagnosed with breast cancer globally.

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What is metastatic or advanced breast cancer?

Metastatic breast cancer—sometimes called advanced or Stage IV breast cancer—is breast cancer that has spread beyond the breast, most commonly to the lungs, bones, liver, and brain. It is the most advanced stage of breast cancer. Even though metastatic breast cancer is in another part of the body, it is still made up of breast cancer cells and is treated as breast cancer. There are a number of treatments and research options for people living with metastatic breast cancer.

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Why are Pfizer’s breast cancer clinical trials being conducted?

These clinical trials are being conducted to see if study medicines may help stop or slow the spread of breast cancer.

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How do I know which Pfizer breast cancer clinical trial is right for me?

Each clinical trial is unique and has different eligibility criteria (also called requirements) to participate. A trial may evaluate a study medicine for a specific type or stage of breast cancer or may be looking for people who have responded in a certain way to previous therapy. Eligibility criteria for each enrolling clinical trial are available on its study webpage.

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What if I am not eligible for any currently enrolling Pfizer breast cancer clinical trials?

If you are not eligible to participate in a Pfizer breast cancer clinical trial at this time, you may visit PfizerLink.com to learn more about Pfizer’s registry, where you can join and potentially be connected to Pfizer clinical trials that may be right for you now and as they become available in the future. 

To search for all registered clinical trials, regarding of the study sponsor, you may visit clinicaltrials.gov.

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Do I have to pay to participate?

The study medicine and any study-related procedures are provided at no cost (these are generally covered by the clinical trial sponsor). You may be reimbursed for any reasonable expenses that you may have as a result of taking part in a Pfizer breast cancer clinical trial. This may include parking, meals, or other travel-related expenses (check with the study team as this may vary).

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Will my information be kept private and confidential?

Your privacy and confidentiality are our priority while participating in our clinical trials. Your personal information will be protected in compliance with relevant laws, and in a manner explained in the informed consent document.

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