Who may participate

Each clinical study has its own guidelines for who may participate, called eligibility criteria. These factors can include your age, sex, overall health, type and stage of disease, and personal treatment history. However, only the research study staff can determine if you qualify to enroll in the study.

Condition
Clostridoides Difficile Associated Disease
Sex
Male or Female
Age
65+ years
Healthy participants
Yes
Visit ClinicalTrials.gov for more information

Eligibility criteria

Study overview

The purpose of the study is to learn about how effective, safe, and tolerable the Clostridioides difficile (C. difficile) vaccine is in decreasing the number of C. difficile infections (pCDI) in adults 65 years of age or older.

The participants will receive either the C. difficile vaccine or placebo (saline). A placebo does not contain any active ingredients. The vaccines will be given as a shot into the upper arm muscle.

This study looks at the number of diarrhea (loose stools) events related to a C. difficile infection, so the length of the study can change. If these events happen quickly, the study may finish sooner; if they happen slowly, it could take longer. Sometimes, the study might stop early if the vaccine clearly does not work. Participants will stay in the study until enough events have occurred to answer the main question. On average, each person is expected to take part for up to about three and a half years.

During this time, participants will have 3 planned clinic visits and 3 planned phone visits. After these visits, more scheduled clinic visits will happen every year until the end of study.

Besides the scheduled study visits, if at any time during the study a participant has 3 or more loose stools in 24 hours, they will be asked to save the next one (the fourth or later) and contact the study site. The study site will check to see if it could be a C. difficile infection. This check may happen at the clinic or through a phone or video call.

View locations for this study

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    Miles
    0500

    Nearest Locations found

    49 sites found

    AMR Clinical

    Newton, Kansas, United States, 67114
    recruiting status
    Recruiting
    Site Info

    Accellacare - McFarland

    Ames, Iowa, United States, 50010
    recruiting status
    Recruiting
    Site Info

    Angels Clinical Research Institute

    Tampa, Florida, United States, 33614
    recruiting status
    Recruiting
    Site Info

    Applied Research Center of Arkansas

    Little Rock, Arkansas, United States, 72205
    recruiting status
    Recruiting
    Site Info

    Atlanta VA Medical Center

    Decatur, Georgia, United States, 30033
    recruiting status
    Recruiting
    Site Info

    Bay Pines VA Healthcare System

    Bay Pines, Florida, United States, 33744
    recruiting status
    Recruiting
    Site Info

    Care Research Inc

    Miami, Florida, United States, 33130
    recruiting status
    Recruiting
    Site Info

    Centricity Research Columbus Georgia Multispecialty

    Columbus, Georgia, United States, 31904
    recruiting status
    Recruiting
    Site Info

    Charisma Medical and Research Center

    Miami Lakes, Florida, United States, 33014
    recruiting status
    Recruiting
    Site Info

    Chinle Center for Indigenous Health

    Chinle, Arizona, United States, 86503
    recruiting status
    Recruiting
    Site Info

    Chinle Comprehensive Health Care Facility

    Chinle, Arizona, United States, 86503
    recruiting status
    Recruiting
    Site Info

    Clinical Neuroscience Solutions, LLC

    Jacksonville, Florida, United States, 32256
    recruiting status
    Recruiting
    Site Info

    DM Clinical Research - Chicago

    Melrose Park, Illinois, United States, 60160
    recruiting status
    Recruiting
    Site Info

    Diablo Clinical Research, Inc.

    Walnut Creek, California, United States, 94598
    recruiting status
    Recruiting
    Site Info

    Emory Steiner Building Research Center

    Atlanta, Georgia, United States, 30303
    recruiting status
    Recruiting
    Site Info

    Emory University Woodruff Extension Building (WEB)

    Atlanta, Georgia, United States, 30303
    recruiting status
    Recruiting
    Site Info

    Entrust Clinical Research

    Miami, Florida, United States, 33176
    recruiting status
    Recruiting
    Site Info

    Epic Medical Research-Sun City

    Sun City, Arizona, United States, 85351
    recruiting status
    Recruiting
    Site Info

    GW Vaccine Research Unit

    Washington D.C., District of Columbia, United States, 20037
    recruiting status
    Recruiting
    Site Info

    Indago Research & Health Center, Inc

    Miami Lakes, Florida, United States, 33016
    recruiting status
    Recruiting
    Site Info

    Kaiser Permanente - San Diego Medical Center

    San Diego, California, United States, 92123
    recruiting status
    Recruiting
    Site Info

    Kaiser Permanente Daly City

    Daly City, California, United States, 94015
    recruiting status
    Recruiting
    Site Info

    Kaiser Permanente Los Angeles Medical Center

    Los Angeles, California, United States, 90027
    recruiting status
    Recruiting
    Site Info

    Kaiser Permanente Oakland

    Oakland, California, United States, 94611
    recruiting status
    Recruiting
    Site Info

    Kaiser Permanente Oncology Pharmacy #014C

    Los Angeles, California, United States, 90027
    recruiting status
    Recruiting
    Site Info

    Kaiser Permanente Ontario Medical Center

    Ontario, California, United States, 91761
    recruiting status
    Recruiting
    Site Info

    Kaiser Permanente Roseville

    Roseville, California, United States, 95661
    recruiting status
    Recruiting
    Site Info

    Kaiser Permanente Sacramento

    Sacramento, California, United States, 95815
    recruiting status
    Recruiting
    Site Info

    Kaiser Permanente San Jose

    San Jose, California, United States, 95119
    recruiting status
    Recruiting
    Site Info

    Kaiser Permanente Santa Clara

    Santa Clara, California, United States, 95051
    recruiting status
    Recruiting
    Site Info

    Kaiser Permanente South Sacramento

    Sacramento, California, United States, 95823
    recruiting status
    Recruiting
    Site Info

    Kaiser Permanente Viewridge Medical Office

    San Diego, California, United States, 92123
    recruiting status
    Recruiting
    Site Info

    Kaiser Permanente Walnut Creek

    Walnut Creek, California, United States, 94596
    recruiting status
    Recruiting
    Site Info

    Lakeview Clinical Research

    Guntersville, Alabama, United States, 35976
    recruiting status
    Recruiting
    Site Info

    M3 Wake Research - Lake City

    Lake City, Florida, United States, 32055
    recruiting status
    Recruiting
    Site Info

    McFarland Clinic, PC

    Ames, Iowa, United States, 50010
    recruiting status
    Recruiting
    Site Info

    Med Partners, Inc. dba Premiere Medical Center of Burbank, Inc.

    Toluca Lake, California, United States, 91602
    recruiting status
    Recruiting
    Site Info

    Medical Affiliated Research Center

    Huntsville, Alabama, United States, 35801
    recruiting status
    Recruiting
    Site Info

    North Alabama Research Center

    Athens, Alabama, United States, 35611
    recruiting status
    Recruiting
    Site Info

    Ochsner Medical Complex - The Grove

    Baton Rouge, Louisiana, United States, 70836
    recruiting status
    Recruiting
    Site Info

    Palm Springs Community Health Center

    Miami Lakes, Florida, United States, 33014
    recruiting status
    Recruiting
    Site Info

    Proactive Clinical Research,LLC

    Fort Lauderdale, Florida, United States, 33308
    recruiting status
    Recruiting
    Site Info

    Sacramento VA Medical Center

    Mather, California, United States, 95655
    recruiting status
    Recruiting
    Site Info

    South Florida Research Organization

    Medley, Florida, United States, 33166
    recruiting status
    Recruiting
    Site Info

    The GW Medical Faculty Associates

    Washington D.C., District of Columbia, United States, 20037
    recruiting status
    Recruiting
    Site Info

    The Hope Clinic of Emory University

    Decatur, Georgia, United States, 30030
    recruiting status
    Recruiting
    Site Info

    Velocity Clinical Research, San Bernardino

    San Bernardino, California, United States, 92408
    recruiting status
    Recruiting
    Site Info

    Velocity Clinical Research, Savannah

    Savannah, Georgia, United States, 31406
    recruiting status
    Recruiting
    Site Info

    Velocity Clinical Research, Sioux City

    Sioux City, Iowa, United States, 51106
    recruiting status
    Recruiting
    Site Info
    • Recruitment Status
    • Site details
    • Study Contact
    • Clinical Trials ID

    Study Locations

    View locations for this studyFind the closest location, your results will be shown belowFind the closest location