Who may participate

Each clinical study has its own guidelines for who may participate, called eligibility criteria. These factors can include your age, sex, overall health, type and stage of disease, and personal treatment history. However, only the research study staff can determine if you qualify to enroll in the study.

Condition
Clostridoides Difficile Associated Disease
Sex
Male or Female
Age
65+ years
Healthy participants
Yes
Visit ClinicalTrials.gov for more information

Eligibility criteria

Study overview

The purpose of the study is to learn about how effective, safe, and tolerable the Clostridioides difficile (C. difficile) vaccine is in decreasing the number of C. difficile infections (pCDI) in adults 65 years of age or older.

The participants will receive either the C. difficile vaccine or placebo (saline). A placebo does not contain any active ingredients. The vaccines will be given as a shot into the upper arm muscle.

This study looks at the number of diarrhea (loose stools) events related to a C. difficile infection, so the length of the study can change. If these events happen quickly, the study may finish sooner; if they happen slowly, it could take longer. Sometimes, the study might stop early if the vaccine clearly does not work. Participants will stay in the study until enough events have occurred to answer the main question. On average, each person is expected to take part for up to about three and a half years.

During this time, participants will have 3 planned clinic visits and 3 planned phone visits. After these visits, more scheduled clinic visits will happen every year until the end of study.

Besides the scheduled study visits, if at any time during the study a participant has 3 or more loose stools in 24 hours, they will be asked to save the next one (the fourth or later) and contact the study site. The study site will check to see if it could be a C. difficile infection. This check may happen at the clinic or through a phone or video call.

View locations for this study

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    Nearest Locations found

    137 sites found

    AMR Clinical

    Newton, Kansas, United States, 67114
    recruiting status
    Recruiting
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    Accellacare - Cary

    Cary, North Carolina, United States, 27518
    recruiting status
    Recruiting
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    Accellacare - Hickory

    Hickory, North Carolina, United States, 28601
    recruiting status
    Recruiting
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    Accellacare - Raleigh

    Raleigh, North Carolina, United States, 27609
    recruiting status
    Recruiting
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    Accellacare - Salisbury

    Salisbury, North Carolina, United States, 28144
    recruiting status
    Recruiting
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    Accellacare - Wilmington

    Wilmington, North Carolina, United States, 28401
    recruiting status
    Recruiting
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    Accellacare - Winston-Salem

    Winston-Salem, North Carolina, United States, 27103
    recruiting status
    Recruiting
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    Albuquerque Clinical Trials, Inc.

    Albuquerque, New Mexico, United States, 87102
    recruiting status
    Recruiting
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    Aso Iizuka Hospital

    Iizuka-shi, Fukuoka, Japan, 820-8505
    recruiting status
    Recruiting
    Site Info

    Atrium Health Wake Forest Baptist Infectious Disease-High Point

    High Point, North Carolina, United States, 27262
    recruiting status
    Recruiting
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    Baylor College of Medicine

    Houston, Texas, United States, 77030
    recruiting status
    Recruiting
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    Brunel Medical Practice (St Marychurch)

    Torquay, Devon, United Kingdom, TQ1 4QX
    recruiting status
    Recruiting
    Site Info

    CDC Centro Médico

    Lujan de Cuyo, Mendoza Province, Argentina, 5505
    recruiting status
    Recruiting
    Site Info

    CTI Clinical Research Center

    Cincinnati, Ohio, United States, 45212
    recruiting status
    Recruiting
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    Capital Area Research, LLC

    Camp Hill, Pennsylvania, United States, 17011
    recruiting status
    Recruiting
    Site Info

    Cedar Health Research - Euless

    Euless, Texas, United States, 76040
    recruiting status
    Recruiting
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    Centro Medico Barrio Parque

    Buenos Aires, Argentina, 1425
    recruiting status
    Recruiting
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    Cheadle Community Hospital

    Cheadle, Staffordshire, United Kingdom, ST10 1NS
    recruiting status
    Recruiting
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    Clinica Del Niño Y La Madre

    Mar del Plata, Buenos Aires, Argentina, 7600
    recruiting status
    Recruiting
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    Clinica Privada del Sol S.A

    Córdoba, Córdoba Province, Argentina, X5000IIH
    recruiting status
    Recruiting
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    Clinical Neuroscience Solutions Inc.

    Memphis, Tennessee, United States, 38119
    recruiting status
    Recruiting
    Site Info

    Clinical Research Partners, LLC

    Richmond, Virginia, United States, 23226
    recruiting status
    Recruiting
    Site Info

    Columbia University Irving Medical Center

    New York, New York, United States, 10032
    recruiting status
    Recruiting
    Site Info

    DM Clinical Research - Detroit

    Southfield, Michigan, United States, 48076
    recruiting status
    Recruiting
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    DM Clinical Research - Philadelphia

    Philadelphia, Pennsylvania, United States, 19107
    recruiting status
    Recruiting
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    DM Clinical Research- Cyfair

    Houston, Texas, United States, 77065
    recruiting status
    Recruiting
    Site Info

    Duke University Health System

    Raleigh, North Carolina, United States, 27609
    recruiting status
    Recruiting
    Site Info

    Duke Vaccine and Trials Unit

    Durham, North Carolina, United States, 27703
    recruiting status
    Recruiting
    Site Info

    Dynamed Clinical Research, LP d/b/a DM Clinical Research

    Tomball, Texas, United States, 77375
    recruiting status
    Recruiting
    Site Info

    Equipo Ciencia

    Buenos Aires, Buenos Aires F.D., Argentina, C1428BNF
    recruiting status
    Recruiting
    Site Info

    Family Health Watch - KeyPoint Clinical Research

    Dallas, Texas, United States, 75237
    recruiting status
    Recruiting
    Site Info

    Fukuoka Shinmizumaki Hospital

    Onga-gun, Fukuoka, Japan, 807-0051
    recruiting status
    Recruiting
    Site Info

    Fundación Huésped

    Buenos Aires, Buenos Aires F.D., Argentina, 1427
    recruiting status
    Recruiting
    Site Info

    Gallup Center for Indigenous Health

    Gallup, New Mexico, United States, 87301
    recruiting status
    Recruiting
    Site Info

    Gallup Indian Medical Center

    Gallup, New Mexico, United States, 87301
    recruiting status
    Recruiting
    Site Info

    HMH David Jurist Research Building

    Hackensack, New Jersey, United States, 07601
    recruiting status
    Recruiting
    Site Info

    HMH Hackensack University Medical Center

    Hackensack, New Jersey, United States, 07601
    recruiting status
    Recruiting
    Site Info

    HOPE Tower at Jersey Shore University Medical Center

    Neptune City, New Jersey, United States, 07753
    recruiting status
    Recruiting
    Site Info

    Hackensack Meridian Health Hackensack University Medical Center

    Hackensack, New Jersey, United States, 07601
    recruiting status
    Recruiting
    Site Info

    Hackensack Meridian Health Jersey Shore University Medical Center

    Neptune City, New Jersey, United States, 07753
    recruiting status
    Recruiting
    Site Info

    Icahn School of Medicine at Mount Sinai

    New York, New York, United States, 10029
    recruiting status
    Recruiting
    Site Info

    Instituto Médico Platense (IMP)

    La Plata, Buenos Aires, Argentina, 1900
    recruiting status
    Recruiting
    Site Info

    Investigaciones Clínicas Salta (ICSAL)

    Salta, Argentina, A4400
    recruiting status
    Recruiting
    Site Info

    J. Lewis Research, Inc. / Foothill Family Clinic South

    Salt Lake City, Utah, United States, 84121
    recruiting status
    Recruiting
    Site Info

    James J. Peters VA Medical Center

    The Bronx, New York, United States, 10468
    recruiting status
    Recruiting
    Site Info

    Japan Community Healthcare Organization Kyushu Hospital

    Kitakyushu-shi, Fukuoka, Japan, 806-8501
    recruiting status
    Recruiting
    Site Info

    Japanese Red Cross Kumamoto Hospital

    Kumamoto, Kumamoto, Japan, 861-8520, 862-8520
    recruiting status
    Recruiting
    Site Info

    Johns Hopkins Bloomberg School of Public Health

    Baltimore, Maryland, United States, 21205
    recruiting status
    Recruiting
    Site Info

    Johns Hopkins Bloomberg School of Public Health

    Baltimore, Maryland, United States, 21231
    recruiting status
    Recruiting
    Site Info

    Kaiser Permanente Center for Health Research

    Portland, Oregon, United States, 97227
    recruiting status
    Recruiting
    Site Info

    Kaiser Permanente Washington Health Research Institute (KPWHRI)

    Seattle, Washington, United States, 98101
    recruiting status
    Recruiting
    Site Info

    Kamiiida daiichi General Hospital

    Nagoya, Aichi-ken, Japan, 462-0802
    recruiting status
    Recruiting
    Site Info

    KeyPoint Clinical Research

    Dallas, Texas, United States, 75240
    recruiting status
    Recruiting
    Site Info

    Knowle House Surgery

    Plymouth, Devon, United Kingdom, PL5 3JB
    recruiting status
    Recruiting
    Site Info

    Koga General Hospital

    Koga, Ibaraki, Japan, 306-0041
    recruiting status
    Recruiting
    Site Info

    Kojunkai Daido Clinic

    Nagoya, Aichi-ken, Japan, 457-8511
    recruiting status
    Recruiting
    Site Info

    Lakeside Surgery

    Corby, Northamptonshire, United Kingdom, NN17 2UR
    recruiting status
    Recruiting
    Site Info

    Layton Medical Centre

    Blackpool, Lancashire, United Kingdom, FY3 7EN
    recruiting status
    Recruiting
    Site Info

    Manchester Royal Infirmary

    Manchester, United Kingdom, M13 9WU
    recruiting status
    Recruiting
    Site Info

    McFarland Clinic, PC

    Ames, Iowa, United States, 50010
    recruiting status
    Recruiting
    Site Info

    Medication Management

    Greensboro, North Carolina, United States, 27405
    recruiting status
    Recruiting
    Site Info

    Memorial Hermann Hospital - TMC

    Houston, Texas, United States, 77030
    recruiting status
    Recruiting
    Site Info

    Mercury Clinical Research - Santa Clara Family Clinic

    Houston, Texas, United States, 77087
    recruiting status
    Recruiting
    Site Info

    Montefiore Medical Center

    The Bronx, New York, United States, 10467
    recruiting status
    Recruiting
    Site Info

    Mount Sinai Morningside

    New York, New York, United States, 10025
    recruiting status
    Recruiting
    Site Info

    Mount Sinai Queens

    Long Island City, New York, United States, 11102
    recruiting status
    Recruiting
    Site Info

    Mount Sinai West

    New York, New York, United States, 10019
    recruiting status
    Recruiting
    Site Info

    NYU Langone Health

    Brooklyn, New York, United States, 11220
    recruiting status
    Recruiting
    Site Info

    NYU Langone Health

    Mineola, New York, United States, 11501
    recruiting status
    Recruiting
    Site Info

    NYU Langone Health

    New York, New York, United States, 10016
    recruiting status
    Recruiting
    Site Info

    Nanbu Tokushukai Hospital

    Shimajiri, Okinawa, Japan, 901-0417
    recruiting status
    Recruiting
    Site Info

    National Center for Global Health and Medicine

    Shinjuku, Tokyo, Japan, 162-8655
    recruiting status
    Recruiting
    Site Info

    National Hospital Organization Nagasaki Medical Center

    Ōmura, Nagasaki, Japan, 856-8562
    recruiting status
    Recruiting
    Site Info

    New Phase Research and Development

    Knoxville, Tennessee, United States, 37909
    recruiting status
    Recruiting
    Site Info

    Newquay Health Centre

    Newquay, Cornwall, United Kingdom, TR7 1RU
    recruiting status
    Recruiting
    Site Info

    North Shore University Hospital

    Manhasset, New York, United States, 11030
    recruiting status
    Recruiting
    Site Info

    North Texas Infectious Diseases Consultants, P.A

    Dallas, Texas, United States, 75246
    recruiting status
    Recruiting
    Site Info

    Northern Navajo Medical Center

    Shiprock, New Mexico, United States, 87420
    recruiting status
    Recruiting
    Site Info

    Northern Westchester Hospital

    Mount Kisco, New York, United States, 10549
    recruiting status
    Recruiting
    Site Info

    Northwell Health Infectious Disease

    Manhasset, New York, United States, 11030
    recruiting status
    Recruiting
    Site Info

    Northwest Houston Heart Center

    Tomball, Texas, United States, 77375
    recruiting status
    Recruiting
    Site Info

    Nozaki Tokushukai Hospital

    Daitō, Osaka, Japan, 574-0074
    recruiting status
    Recruiting
    Site Info

    Ochsner Clinic Foundation - Kenner Clinical Trials Unit

    Kenner, Louisiana, United States, 70065
    recruiting status
    Recruiting
    Site Info

    Ochsner Lafayette General Medical Center

    Lafayette, Louisiana, United States, 70503
    recruiting status
    Recruiting
    Site Info

    Ochsner Medical Complex - The Grove

    Baton Rouge, Louisiana, United States, 70836
    recruiting status
    Recruiting
    Site Info

    Ormeau Clinical Trials

    Belfast, Northern Ireland, United Kingdom, BT2 8BG
    recruiting status
    Recruiting
    Site Info

    Panthera Biopartners - Glasgow

    Glasgow, United Kingdom, G51 4RY
    recruiting status
    Recruiting
    Site Info

    Panthera Biopartners - Manchester

    Rochdale, Manchester, United Kingdom, OL11 4AU
    recruiting status
    Recruiting
    Site Info

    Panthera Biopartners - Preston

    Preston, England, United Kingdom, PR2 9QB
    recruiting status
    Recruiting
    Site Info

    Panthera Biopartners - Sheffield

    Sheffield, United Kingdom, S2 5FX
    recruiting status
    Recruiting
    Site Info

    Panthera Clinic - York

    York, North Yorkshire, United Kingdom, YO24 4LJ
    recruiting status
    Recruiting
    Site Info

    Phelps Hospital Geriatric Medicine & Improvement Science

    Sleepy Hollow, New York, United States, 10591
    recruiting status
    Recruiting
    Site Info

    Providence Regional Medical Center Everett

    Everett, Washington, United States, 98201
    recruiting status
    Recruiting
    Site Info

    Raleigh Medical Group P.A.

    Raleigh, North Carolina, United States, 27609
    recruiting status
    Recruiting
    Site Info

    Renown Center for Advanced Medicine

    Reno, Nevada, United States, 89502
    recruiting status
    Recruiting
    Site Info

    Renown Regional Medical Center

    Reno, Nevada, United States, 89502
    recruiting status
    Recruiting
    Site Info

    Revive Research Institute, Inc.

    Southfield, Michigan, United States, 48075
    recruiting status
    Recruiting
    Site Info

    Rochester Clinical Research, LLC

    Rochester, New York, United States, 14609
    recruiting status
    Recruiting
    Site Info

    Royal Devon & Exeter Hospital

    Exeter, Devon, United Kingdom, EX2 5DW
    recruiting status
    Recruiting
    Site Info

    Rutgers Robert Wood Johnson Medical School

    New Brunswick, New Jersey, United States, 08901
    recruiting status
    Recruiting
    Site Info

    Saga University Hospital

    Saga, Saga-ken, Japan, 849-8501
    recruiting status
    Recruiting
    Site Info

    Sanatorio Sagrado Corazón

    Buenos Aires, Argentina, 1039
    recruiting status
    Recruiting
    Site Info

    Seishinkai Inoue Hospital

    Itoshima, Fukuoka, Japan, 819-1104
    recruiting status
    Recruiting
    Site Info

    Shiprock Center for Indigenous Health

    Shiprock, New Mexico, United States, 87420
    recruiting status
    Recruiting
    Site Info

    South Jersey Infectious Disease

    Somers Point, New Jersey, United States, 08244
    recruiting status
    Recruiting
    Site Info

    Southampton General Hospital

    Southampton, Hampshire, United Kingdom, SO16 6YD
    recruiting status
    Recruiting
    Site Info

    Staten Island University Hospital

    Staten Island, New York, United States, 10305
    recruiting status
    Recruiting
    Site Info

    Sundance Clinical Research

    St Louis, Missouri, United States, 63141
    recruiting status
    Recruiting
    Site Info

    Synexus Manchester Clinical Research Centre

    Manchester, United Kingdom, M15 6SE
    recruiting status
    Recruiting
    Site Info

    Synexus Midlands Clinical Research Centre

    Birmingham, United Kingdom, B16 8QQ
    recruiting status
    Recruiting
    Site Info

    The University of Texas Health Science Center at Houston

    Houston, Texas, United States, 77030
    recruiting status
    Recruiting
    Site Info

    The University of Vermont Medical Center Inc.

    Burlington, Vermont, United States, 05401
    recruiting status
    Recruiting
    Site Info

    The Vanderbilt Vaccine Research Program Clinic at The Village at Vanderbilt

    Nashville, Tennessee, United States, 37212
    recruiting status
    Recruiting
    Site Info

    Tokyo-Eki Center-building Clinic

    Chuo-ku, Tokyo, Japan, 103-0027
    recruiting status
    Recruiting
    Site Info

    UT Physicians

    Houston, Texas, United States, 77030
    recruiting status
    Recruiting
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    UVM Larner College of Medicine MMG/VCT

    Burlington, Vermont, United States, 05401
    recruiting status
    Recruiting
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    University Health

    Reno, Nevada, United States, 89519
    recruiting status
    Recruiting
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    University Of Nebraska Medical Center

    Omaha, Nebraska, United States, 68198
    recruiting status
    Recruiting
    Site Info

    University of Nebraska Medical Center

    Omaha, Nebraska, United States, 68105
    recruiting status
    Recruiting
    Site Info

    University of Washington - Harborview Medical Center

    Seattle, Washington, United States, 98104
    recruiting status
    Recruiting
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    Upstate Global Health Institute

    East Syracuse, New York, United States, 13057
    recruiting status
    Recruiting
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    VA Boston Healthcare System - West Roxbury

    West Roxbury, Massachusetts, United States, 02132
    recruiting status
    Recruiting
    Site Info

    VA Northeast Ohio Healthcare System Louis Stokes Cleveland VA Medical Center

    Cleveland, Ohio, United States, 44106
    recruiting status
    Recruiting
    Site Info

    Vanderbilt Investigational Drug Service (IDS)

    Nashville, Tennessee, United States, 37232
    recruiting status
    Recruiting
    Site Info

    Vanderbilt University Medical Center

    Nashville, Tennessee, United States, 37232
    recruiting status
    Recruiting
    Site Info

    Vanderbilt Vaccine Research Program

    Nashville, Tennessee, United States, 37232
    recruiting status
    Recruiting
    Site Info

    Vanderbilt Vaccine Research Program Laboratory

    Nashville, Tennessee, United States, 37232
    recruiting status
    Recruiting
    Site Info

    Velocity Clinical Research, Grand Island

    Grand Island, Nebraska, United States, 68803
    recruiting status
    Recruiting
    Site Info

    Velocity Clinical Research, Omaha

    Omaha, Nebraska, United States, 68134
    recruiting status
    Recruiting
    Site Info

    Velocity Clinical Research, Sioux City

    Sioux City, Iowa, United States, 51106
    recruiting status
    Recruiting
    Site Info

    Velocity Clinical Research, Spartanburg

    Spartanburg, South Carolina, United States, 29303
    recruiting status
    Recruiting
    Site Info

    Wake Forest Baptist Health

    Winston-Salem, North Carolina, United States, 27157
    recruiting status
    Recruiting
    Site Info

    Walker Family Care

    Little River, South Carolina, United States, 29566
    recruiting status
    Recruiting
    Site Info

    Washington University School of Medicine

    St Louis, Missouri, United States, 63110
    recruiting status
    Recruiting
    Site Info

    Wilmington Health, PLLC

    Wilmington, North Carolina, United States, 28401
    recruiting status
    Recruiting
    Site Info

    North Wales Clinical Research Facility

    Wrexham, Wrexham [wrecsam Gb-wrc], United Kingdom, LL13 7YP
    not yet recruiting status
    Not yet recruiting
    Site Info

    Synexus Scotland Clinical Research Centre

    Glasgow, Glasgow CITY, United Kingdom, ML4 3NJ
    not yet recruiting status
    Not yet recruiting
    Site Info
    • Recruitment Status
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    • Clinical Trials ID

    Study Locations

    View locations for this studyFind the closest location, your results will be shown belowFind the closest location