Who may participate

Each clinical study has its own guidelines for who may participate, called eligibility criteria. These factors can include your age, sex, overall health, type and stage of disease, and personal treatment history. However, only the research study staff can determine if you qualify to enroll in the study.

Condition
Clostridioides Difficile Associated Disease
Sex
Male or Female
Age
65+ years
Healthy participants
Yes

Eligibility criteria

Study overview

The purpose of the study is to learn about how effective, safe, and tolerable the Clostridioides difficile (C. difficile) vaccine is in decreasing the number of C. difficile infections (pCDI) in adults 65 years of age or older.

The participants will receive either the C. difficile vaccine or placebo (saline). A placebo does not contain any active ingredients. The vaccines will be given as a shot into the upper arm muscle.

This study looks at the number of diarrhea (loose stools) events related to a C. difficile infection, so the length of the study can change. If these events happen quickly, the study may finish sooner; if they happen slowly, it could take longer. Sometimes, the study might stop early if the vaccine clearly works or clearly doesn't. Participants will stay in the study until enough events have occurred to answer the main question. On average, each person is expected to take part for up to about three and a half years.

During this time, participants will have 3 planned clinical visits and 3 planned phone visits. After these visits, more scheduled clinic visits will happen every year until the end of study.

Besides the scheduled study visits, if at any time during the study a participant has 3 or more loose stools in 24 hours, they will be asked to save the next one (the fourth or later) and contact the study site. The study site will check to see if it could be a C. difficile infection. This check may happen at the clinic or through a phone or video call.

View locations for this study

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    Miles
    0500

    Nearest Locations found

    64 sites found

    AMR Clinical

    Newton, Kansas, United States, 67114
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    Accellacare - Cary

    Cary, North Carolina, United States, 27518
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    Accellacare - Hickory

    Hickory, North Carolina, United States, 28601
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    Accellacare - McFarland

    Ames, Iowa, United States, 50010
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    Accellacare - Raleigh

    Raleigh, North Carolina, United States, 27609
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    Accellacare - Salisbury

    Salisbury, North Carolina, United States, 28144
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    Accellacare - Wilmington

    Wilmington, North Carolina, United States, 28401
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    Accellacare - Winston-Salem

    Winston-Salem, North Carolina, United States, 27103
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    Angels Clinical Research Institute

    Tampa, Florida, United States, 33614
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    Applied Research Center of Arkansas

    Little Rock, Arkansas, United States, 72205
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    CTI Clinical Research Center

    Cincinnati, Ohio, United States, 45212
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    Capital Area Research, LLC

    Camp Hill, Pennsylvania, United States, 17011
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    Carbon Health - San Mateo - Hillsdale Mall

    San Mateo, California, United States, 94403
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    Care Research Inc

    Miami, Florida, United States, 33130
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    Cedar Health Research - Euless

    Euless, Texas, United States, 76040
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    Centricity Research Columbus Georgia Multispecialty

    Columbus, Georgia, United States, 31904
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    Charisma Medical and Research Center

    Miami Lakes, Florida, United States, 33014
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    Clinical Neuroscience Solutions Inc.

    Memphis, Tennessee, United States, 38119
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    Clinical Neuroscience Solutions, Inc. dba CNS Healthcare

    Jacksonville, Florida, United States, 32256
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    Clinical Research Partners, LLC

    Richmond, Virginia, United States, 23226
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    DM Clinical Research - Chicago

    Melrose Park, Illinois, United States, 60160
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    DM Clinical Research - Detroit

    Southfield, Michigan, United States, 48076
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    DM Clinical Research - Philadelphia

    Philadelphia, Pennsylvania, United States, 19107
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    DM Clinical Research- Cyfair

    Houston, Texas, United States, 77065
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    Diablo Clinical Research, Inc.

    Walnut Creek, California, United States, 94598
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    Dynamed Clinical Research, LP d/b/a DM Clinical Research

    Tomball, Texas, United States, 77375
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    Entrust Clinical Research

    Miami, Florida, United States, 33176
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    Epic Medical Research-Sun City

    Sun City, Arizona, United States, 85351
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    Equipo Ciencia

    Buenos Aires, Buenos Aires F.D., Argentina, C1428BNF
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    Family Health Watch - KeyPoint Clinical Research

    Dallas, Texas, United States, 75237
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    GW Vaccine Research Unit

    Washington D.C., District of Columbia, United States, 20037
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    Indago Research & Health Center, Inc

    Hialeah, Florida, United States, 33012
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    Innovation Medical Research Center

    Palmetto Bay, Florida, United States, 33157
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    J. Lewis Research, Inc. / Foothill Family Clinic South

    Salt Lake City, Utah, United States, 84121
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    Kaiser Permanente Center for Health Research

    Portland, Oregon, United States, 97227
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    KeyPoint Clinical Research

    Dallas, Texas, United States, 75240
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    Lakeview Clinical Research

    Guntersville, Alabama, United States, 35976
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    M3 Wake Research - Lake City

    Lake City, Florida, United States, 32055
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    McFarland Clinic, PC

    Ames, Iowa, United States, 50010
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    Med Partners, Inc. dba Premiere Medical Center of Burbank, Inc.

    Toluca Lake, California, United States, 91602
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    Medical Affiliated Research Center

    Huntsville, Alabama, United States, 35801
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    Medication Management

    Greensboro, North Carolina, United States, 27405
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    Mercury Clinical Research - Santa Clara Family Clinic

    Houston, Texas, United States, 77087
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    New Phase Research and Development

    Knoxville, Tennessee, United States, 37909
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    North Alabama Research Center

    Athens, Alabama, United States, 35611
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    Northwest Houston Heart Center

    Tomball, Texas, United States, 77375
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    Palm Springs Community Health Center

    Miami Lakes, Florida, United States, 33014
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    Proactive Clinical Research,LLC

    Fort Lauderdale, Florida, United States, 33308
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    Renown Center for Advanced Medicine

    Reno, Nevada, United States, 89502
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    Renown Regional Medical Center

    Reno, Nevada, United States, 89502
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    Revive Research Institute, Inc.

    Southfield, Michigan, United States, 48075
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    Rochester Clinical Research, LLC

    Rochester, New York, United States, 14609
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    South Florida Research Organization

    Medley, Florida, United States, 33166
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    South Jersey Infectious Disease

    Somers Point, New Jersey, United States, 08244
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    Sundance Clinical Research

    St Louis, Missouri, United States, 63141
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    The GW Medical Faculty Associates

    Washington D.C., District of Columbia, United States, 20037
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    Trial Management Associates

    Myrtle Beach, South Carolina, United States, 29572
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    Trial Management Associates, LLC

    Myrtle Beach, South Carolina, United States, 29572
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    University Health

    Reno, Nevada, United States, 89519
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    Velocity Clinical Research, Grand Island

    Grand Island, Nebraska, United States, 68803
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    Velocity Clinical Research, Omaha

    Omaha, Nebraska, United States, 68134
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    Velocity Clinical Research, San Bernardino

    San Bernardino, California, United States, 92408
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    Velocity Clinical Research, Sioux City

    Sioux City, Iowa, United States, 51106
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    Walker Family Care

    Little River, South Carolina, United States, 29566
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    • Recruitment Status
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    Study Locations

    View locations for this studyFind the closest location, your results will be shown belowFind the closest location