Who may participate

Each clinical study has its own guidelines for who may participate, called eligibility criteria. These factors can include your age, sex, overall health, type and stage of disease, and personal treatment history. However, only the research study staff can determine if you qualify to enroll in the study.

Condition
Clostridioides Difficile Associated Disease
Sex
Male or Female
Age
65+ years
Healthy participants
Yes
Visit ClinicalTrials.gov for more information

Eligibility criteria

Study overview

The purpose of the study is to learn about how effective, safe, and tolerable the Clostridioides difficile (C. difficile) vaccine is in decreasing the number of C. difficile infections (pCDI) in adults 65 years of age or older.

The participants will receive either the C. difficile vaccine or placebo (saline). A placebo does not contain any active ingredients. The vaccines will be given as a shot into the upper arm muscle.

This study looks at the number of diarrhea (loose stools) events related to a C. difficile infection, so the length of the study can change. If these events happen quickly, the study may finish sooner; if they happen slowly, it could take longer. Sometimes, the study might stop early if the vaccine clearly works or clearly doesn't. Participants will stay in the study until enough events have occurred to answer the main question. On average, each person is expected to take part for up to about three and a half years.

During this time, participants will have 3 planned clinical visits and 3 planned phone visits. After these visits, more scheduled clinic visits will happen every year until the end of study.

Besides the scheduled study visits, if at any time during the study a participant has 3 or more loose stools in 24 hours, they will be asked to save the next one (the fourth or later) and contact the study site. The study site will check to see if it could be a C. difficile infection. This check may happen at the clinic or through a phone or video call.

View locations for this study

Find the closest location, your results will be shown below
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    Miles
    0500

    Nearest Locations found

    83 sites found

    Accellacare - Hickory

    Hickory, North Carolina, United States, 28601
    recruiting status
    Recruiting
    Site Info

    Applied Research Center of Arkansas

    Little Rock, Arkansas, United States, 72205
    recruiting status
    Recruiting
    Site Info

    CTI Clinical Research Center

    Cincinnati, Ohio, United States, 45212
    recruiting status
    Recruiting
    Site Info

    Charisma Medical and Research Center

    Miami Lakes, Florida, United States, 33014
    recruiting status
    Recruiting
    Site Info

    DM Clinical Research - Detroit

    Southfield, Michigan, United States, 48076
    recruiting status
    Recruiting
    Site Info

    DM Clinical Research- Cyfair

    Houston, Texas, United States, 77065
    recruiting status
    Recruiting
    Site Info

    Diablo Clinical Research, Inc.

    Walnut Creek, California, United States, 94598
    recruiting status
    Recruiting
    Site Info

    Epic Medical Research-Sun City

    Sun City, Arizona, United States, 85351
    recruiting status
    Recruiting
    Site Info

    Indago Research & Health Center, Inc

    Hialeah, Florida, United States, 33012
    recruiting status
    Recruiting
    Site Info

    J. Lewis Research, Inc. / Foothill Family Clinic South

    Salt Lake City, Utah, United States, 84121
    recruiting status
    Recruiting
    Site Info

    Lakeview Clinical Research

    Guntersville, Alabama, United States, 35976
    recruiting status
    Recruiting
    Site Info

    Mercury Clinical Research - Santa Clara Family Clinic

    Houston, Texas, United States, 77087
    recruiting status
    Recruiting
    Site Info

    New Phase Research and Development

    Knoxville, Tennessee, United States, 37909
    recruiting status
    Recruiting
    Site Info

    North Alabama Research Center

    Athens, Alabama, United States, 35611
    recruiting status
    Recruiting
    Site Info

    Northwest Houston Heart Center

    Tomball, Texas, United States, 77375
    recruiting status
    Recruiting
    Site Info

    Proactive Clinical Research,LLC

    Fort Lauderdale, Florida, United States, 33308
    recruiting status
    Recruiting
    Site Info

    Revive Research Institute, Inc.

    Southfield, Michigan, United States, 48075
    recruiting status
    Recruiting
    Site Info

    South Florida Research Organization

    Medley, Florida, United States, 33166
    recruiting status
    Recruiting
    Site Info

    South Jersey Infectious Disease

    Somers Point, New Jersey, United States, 08244
    recruiting status
    Recruiting
    Site Info

    Velocity Clinical Research, Grand Island

    Grand Island, Nebraska, United States, 68803
    recruiting status
    Recruiting
    Site Info

    Velocity Clinical Research, San Bernardino

    San Bernardino, California, United States, 92408
    recruiting status
    Recruiting
    Site Info

    Walker Family Care

    Little River, South Carolina, United States, 29566
    recruiting status
    Recruiting
    Site Info

    AMR Clinical

    Newton, Kansas, United States, 67114
    not yet recruiting status
    Not yet recruiting
    Site Info

    Accellacare - Cary

    Cary, North Carolina, United States, 27518
    not yet recruiting status
    Not yet recruiting
    Site Info

    Accellacare - McFarland

    Ames, Iowa, United States, 50010
    not yet recruiting status
    Not yet recruiting
    Site Info

    Accellacare - Raleigh

    Raleigh, North Carolina, United States, 27609
    not yet recruiting status
    Not yet recruiting
    Site Info

    Accellacare - Salisbury

    Salisbury, North Carolina, United States, 28144
    not yet recruiting status
    Not yet recruiting
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    Accellacare - Wilmington

    Wilmington, North Carolina, United States, 28401
    not yet recruiting status
    Not yet recruiting
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    Accellacare - Winston-Salem

    Winston-Salem, North Carolina, United States, 27103
    not yet recruiting status
    Not yet recruiting
    Site Info

    Albuquerque Clinical Trials, Inc.

    Albuquerque, New Mexico, United States, 87102
    not yet recruiting status
    Not yet recruiting
    Site Info

    Angels Clinical Research Institute

    Tampa, Florida, United States, 33614
    not yet recruiting status
    Not yet recruiting
    Site Info

    Brunel Medical Practice (St Marychurch)

    Torquay, Devon, United Kingdom, TQ1 4QX
    not yet recruiting status
    Not yet recruiting
    Site Info

    Capital Area Research, LLC

    Camp Hill, Pennsylvania, United States, 17011
    not yet recruiting status
    Not yet recruiting
    Site Info

    Carbon Health - San Mateo - Hillsdale Mall

    San Mateo, California, United States, 94403
    not yet recruiting status
    Not yet recruiting
    Site Info

    Care Research Inc

    Miami, Florida, United States, 33130
    not yet recruiting status
    Not yet recruiting
    Site Info

    Cedar Health Research - Euless

    Euless, Texas, United States, 76040
    not yet recruiting status
    Not yet recruiting
    Site Info

    Centricity Research Columbus Georgia Multispecialty

    Columbus, Georgia, United States, 31904
    not yet recruiting status
    Not yet recruiting
    Site Info

    Clinical Neuroscience Solutions Inc.

    Memphis, Tennessee, United States, 38119
    not yet recruiting status
    Not yet recruiting
    Site Info

    Clinical Neuroscience Solutions, Inc. dba CNS Healthcare

    Jacksonville, Florida, United States, 32256
    not yet recruiting status
    Not yet recruiting
    Site Info

    Clinical Research Partners, LLC

    Richmond, Virginia, United States, 23226
    not yet recruiting status
    Not yet recruiting
    Site Info

    DM Clinical Research - Chicago

    Melrose Park, Illinois, United States, 60160
    not yet recruiting status
    Not yet recruiting
    Site Info

    DM Clinical Research - Philadelphia

    Philadelphia, Pennsylvania, United States, 19107
    not yet recruiting status
    Not yet recruiting
    Site Info

    Dynamed Clinical Research, LP d/b/a DM Clinical Research

    Tomball, Texas, United States, 77375
    not yet recruiting status
    Not yet recruiting
    Site Info

    Entrust Clinical Research

    Miami, Florida, United States, 33176
    not yet recruiting status
    Not yet recruiting
    Site Info

    Equipo Ciencia

    Buenos Aires, Buenos Aires F.D., Argentina, C1428BNF
    not yet recruiting status
    Not yet recruiting
    Site Info

    Family Health Watch - KeyPoint Clinical Research

    Dallas, Texas, United States, 75237
    not yet recruiting status
    Not yet recruiting
    Site Info

    GW Vaccine Research Unit

    Washington D.C., District of Columbia, United States, 20037
    not yet recruiting status
    Not yet recruiting
    Site Info

    Innovation Medical Research Center

    Palmetto Bay, Florida, United States, 33157
    not yet recruiting status
    Not yet recruiting
    Site Info

    Kaiser Permanente Center for Health Research

    Portland, Oregon, United States, 97227
    not yet recruiting status
    Not yet recruiting
    Site Info

    KeyPoint Clinical Research

    Dallas, Texas, United States, 75240
    not yet recruiting status
    Not yet recruiting
    Site Info

    Knowle House Surgery

    Plymouth, Devon, United Kingdom, PL5 3JB
    not yet recruiting status
    Not yet recruiting
    Site Info

    Lakeside Surgery

    Corby, Northamptonshire, United Kingdom, NN17 2UR
    not yet recruiting status
    Not yet recruiting
    Site Info

    M3 Wake Research - Lake City

    Lake City, Florida, United States, 32055
    not yet recruiting status
    Not yet recruiting
    Site Info

    McFarland Clinic, PC

    Ames, Iowa, United States, 50010
    not yet recruiting status
    Not yet recruiting
    Site Info

    Med Partners, Inc. dba Premiere Medical Center of Burbank, Inc.

    Toluca Lake, California, United States, 91602
    not yet recruiting status
    Not yet recruiting
    Site Info

    Medical Affiliated Research Center

    Huntsville, Alabama, United States, 35801
    not yet recruiting status
    Not yet recruiting
    Site Info

    Medication Management

    Greensboro, North Carolina, United States, 27405
    not yet recruiting status
    Not yet recruiting
    Site Info

    Newquay Health Centre

    Newquay, Cornwall, United Kingdom, TR7 1RU
    not yet recruiting status
    Not yet recruiting
    Site Info

    Palm Springs Community Health Center

    Miami Lakes, Florida, United States, 33014
    not yet recruiting status
    Not yet recruiting
    Site Info

    Panthera Biopartners - Glasgow

    Glasgow, Scotland, United Kingdom, G51 4TY
    not yet recruiting status
    Not yet recruiting
    Site Info

    Panthera Biopartners - Manchester

    Rochdale, Manchester, United Kingdom, OL11 4AU
    not yet recruiting status
    Not yet recruiting
    Site Info

    Panthera Biopartners - Preston

    Preston, England, United Kingdom, PR2 9QB
    not yet recruiting status
    Not yet recruiting
    Site Info

    Panthera Biopartners - Sheffield

    Sheffield, United Kingdom, S2 5FX
    not yet recruiting status
    Not yet recruiting
    Site Info

    Panthera Clinic - York

    York, North Yorkshire, United Kingdom, YO24 4LJ
    not yet recruiting status
    Not yet recruiting
    Site Info

    Renown Center for Advanced Medicine

    Reno, Nevada, United States, 89502
    not yet recruiting status
    Not yet recruiting
    Site Info

    Renown Regional Medical Center

    Reno, Nevada, United States, 89502
    not yet recruiting status
    Not yet recruiting
    Site Info

    Rochester Clinical Research, LLC

    Rochester, New York, United States, 14609
    not yet recruiting status
    Not yet recruiting
    Site Info

    Royal Devon & Exeter Hospital

    Exeter, Devon, United Kingdom, EX2 5DW
    not yet recruiting status
    Not yet recruiting
    Site Info

    Sanatorio Sagrado Corazón

    Buenos Aires, Argentina, 1039
    not yet recruiting status
    Not yet recruiting
    Site Info

    Sundance Clinical Research

    St Louis, Missouri, United States, 63141
    not yet recruiting status
    Not yet recruiting
    Site Info

    Synexus Manchester Clinical Research Centre

    Manchester, United Kingdom, M15 6SE
    not yet recruiting status
    Not yet recruiting
    Site Info

    Synexus Midlands Clinical Research Centre

    Birmingham, United Kingdom, B15 2SQ
    not yet recruiting status
    Not yet recruiting
    Site Info

    Synexus Scotland Clinical Research Centre

    Glasgow, Glasgow CITY, United Kingdom, ML4 3NJ
    not yet recruiting status
    Not yet recruiting
    Site Info

    The GW Medical Faculty Associates

    Washington D.C., District of Columbia, United States, 20037
    not yet recruiting status
    Not yet recruiting
    Site Info

    Trial Management Associates

    Myrtle Beach, South Carolina, United States, 29572
    not yet recruiting status
    Not yet recruiting
    Site Info

    Trial Management Associates, LLC

    Myrtle Beach, South Carolina, United States, 29572
    not yet recruiting status
    Not yet recruiting
    Site Info

    University Health

    Reno, Nevada, United States, 89519
    not yet recruiting status
    Not yet recruiting
    Site Info

    University of Washington - Harborview Medical Center

    Seattle, Washington, United States, 98104
    not yet recruiting status
    Not yet recruiting
    Site Info

    Upstate Global Health Institute

    East Syracuse, New York, United States, 13057
    not yet recruiting status
    Not yet recruiting
    Site Info

    Velocity Clinical Research, Omaha

    Omaha, Nebraska, United States, 68134
    not yet recruiting status
    Not yet recruiting
    Site Info

    Velocity Clinical Research, Savannah

    Savannah, Georgia, United States, 31406
    not yet recruiting status
    Not yet recruiting
    Site Info

    Velocity Clinical Research, Sioux City

    Sioux City, Iowa, United States, 51106
    not yet recruiting status
    Not yet recruiting
    Site Info

    Velocity Clinical Research, Spartanburg

    Spartanburg, South Carolina, United States, 29303
    not yet recruiting status
    Not yet recruiting
    Site Info
    • Recruitment Status
    • Site details
    • Study Contact
    • Clinical Trials ID

    Study Locations

    View locations for this studyFind the closest location, your results will be shown belowFind the closest location