Who may participate

Each clinical study has its own guidelines for who may participate, called eligibility criteria. These factors can include your age, sex, overall health, type and stage of disease, and personal treatment history. However, only the research study staff can determine if you qualify to enroll in the study.

Condition
Clostridioides Difficile Associated Disease
Sex
Male or Female
Age
65+ years
Healthy participants
Yes
Visit ClinicalTrials.gov for more information

Eligibility criteria

Study overview

The purpose of the study is to learn about how effective, safe, and tolerable the Clostridioides difficile (C. difficile) vaccine is in decreasing the number of C. difficile infections (pCDI) in adults 65 years of age or older.

The participants will receive either the C. difficile vaccine or placebo (saline). A placebo does not contain any active ingredients. The vaccines will be given as a shot into the upper arm muscle.

This study looks at the number of diarrhea (loose stools) events related to a C. difficile infection, so the length of the study can change. If these events happen quickly, the study may finish sooner; if they happen slowly, it could take longer. Sometimes, the study might stop early if the vaccine clearly works or clearly doesn't. Participants will stay in the study until enough events have occurred to answer the main question. On average, each person is expected to take part for up to about three and a half years.

During this time, participants will have 3 planned clinical visits and 3 planned phone visits. After these visits, more scheduled clinic visits will happen every year until the end of study.

Besides the scheduled study visits, if at any time during the study a participant has 3 or more loose stools in 24 hours, they will be asked to save the next one (the fourth or later) and contact the study site. The study site will check to see if it could be a C. difficile infection. This check may happen at the clinic or through a phone or video call.

View locations for this study

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    Nearest Locations found

    138 sites found

    AMR Clinical

    Newton, Kansas, United States, 67114
    recruiting status
    Recruiting
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    Accellacare - Cary

    Cary, North Carolina, United States, 27518
    recruiting status
    Recruiting
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    Accellacare - Hickory

    Hickory, North Carolina, United States, 28601
    recruiting status
    Recruiting
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    Accellacare - McFarland

    Ames, Iowa, United States, 50010
    recruiting status
    Recruiting
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    Accellacare - Raleigh

    Raleigh, North Carolina, United States, 27609
    recruiting status
    Recruiting
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    Accellacare - Salisbury

    Salisbury, North Carolina, United States, 28144
    recruiting status
    Recruiting
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    Accellacare - Wilmington

    Wilmington, North Carolina, United States, 28401
    recruiting status
    Recruiting
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    Accellacare - Winston-Salem

    Winston-Salem, North Carolina, United States, 27103
    recruiting status
    Recruiting
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    Albuquerque Clinical Trials, Inc.

    Albuquerque, New Mexico, United States, 87102
    recruiting status
    Recruiting
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    Angels Clinical Research Institute

    Tampa, Florida, United States, 33614
    recruiting status
    Recruiting
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    Applied Research Center of Arkansas

    Little Rock, Arkansas, United States, 72205
    recruiting status
    Recruiting
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    Atrium Health Wake Forest Baptist Infectious Disease-High Point

    High Point, North Carolina, United States, 27262
    recruiting status
    Recruiting
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    CTI Clinical Research Center

    Cincinnati, Ohio, United States, 45212
    recruiting status
    Recruiting
    Site Info

    Capital Area Research, LLC

    Camp Hill, Pennsylvania, United States, 17011
    recruiting status
    Recruiting
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    Carbon Health - San Mateo - Hillsdale Mall

    San Mateo, California, United States, 94403
    recruiting status
    Recruiting
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    Care Research Inc

    Miami, Florida, United States, 33130
    recruiting status
    Recruiting
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    Cedar Health Research - Euless

    Euless, Texas, United States, 76040
    recruiting status
    Recruiting
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    Centricity Research Columbus Georgia Multispecialty

    Columbus, Georgia, United States, 31904
    recruiting status
    Recruiting
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    Centro Medico Barrio Parque

    Buenos Aires, Argentina, 1425
    recruiting status
    Recruiting
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    Charisma Medical and Research Center

    Miami Lakes, Florida, United States, 33014
    recruiting status
    Recruiting
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    Clinica Del Niño Y La Madre

    Mar del Plata, Buenos Aires, Argentina, 7600
    recruiting status
    Recruiting
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    Clinica Privada del Sol S.A

    Córdoba, Córdoba Province, Argentina, X5000IIH
    recruiting status
    Recruiting
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    Clinical Neuroscience Solutions Inc.

    Memphis, Tennessee, United States, 38119
    recruiting status
    Recruiting
    Site Info

    Clinical Neuroscience Solutions, Inc. dba CNS Healthcare

    Jacksonville, Florida, United States, 32256
    recruiting status
    Recruiting
    Site Info

    DM Clinical Research - Chicago

    Melrose Park, Illinois, United States, 60160
    recruiting status
    Recruiting
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    DM Clinical Research - Detroit

    Southfield, Michigan, United States, 48076
    recruiting status
    Recruiting
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    DM Clinical Research - Philadelphia

    Philadelphia, Pennsylvania, United States, 19107
    recruiting status
    Recruiting
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    DM Clinical Research- Cyfair

    Houston, Texas, United States, 77065
    recruiting status
    Recruiting
    Site Info

    Diablo Clinical Research, Inc.

    Walnut Creek, California, United States, 94598
    recruiting status
    Recruiting
    Site Info

    Duke University Health System

    Raleigh, North Carolina, United States, 27609
    recruiting status
    Recruiting
    Site Info

    Duke Vaccine and Trials Unit

    Durham, North Carolina, United States, 27703
    recruiting status
    Recruiting
    Site Info

    Dynamed Clinical Research, LP d/b/a DM Clinical Research

    Tomball, Texas, United States, 77375
    recruiting status
    Recruiting
    Site Info

    Entrust Clinical Research

    Miami, Florida, United States, 33176
    recruiting status
    Recruiting
    Site Info

    Epic Medical Research-Sun City

    Sun City, Arizona, United States, 85351
    recruiting status
    Recruiting
    Site Info

    Equipo Ciencia

    Buenos Aires, Buenos Aires F.D., Argentina, C1428BNF
    recruiting status
    Recruiting
    Site Info

    Family Health Watch - KeyPoint Clinical Research

    Dallas, Texas, United States, 75237
    recruiting status
    Recruiting
    Site Info

    Fundación Huésped

    Buenos Aires, Buenos Aires F.D., Argentina, 1427
    recruiting status
    Recruiting
    Site Info

    GW Vaccine Research Unit

    Washington D.C., District of Columbia, United States, 20037
    recruiting status
    Recruiting
    Site Info

    HMH David Jurist Research Building

    Hackensack, New Jersey, United States, 07601
    recruiting status
    Recruiting
    Site Info

    HMH Hackensack University Medical Center

    Hackensack, New Jersey, United States, 07601
    recruiting status
    Recruiting
    Site Info

    HOPE Tower at Jersey Shore University Medical Center

    Neptune City, New Jersey, United States, 07753
    recruiting status
    Recruiting
    Site Info

    Hackensack Meridian Health Hackensack University Medical Center

    Hackensack, New Jersey, United States, 07601
    recruiting status
    Recruiting
    Site Info

    Hackensack Meridian Jersey Shore University Medical Center

    Neptune City, New Jersey, United States, 07753
    recruiting status
    Recruiting
    Site Info

    Icahn School of Medicine at Mount Sinai

    New York, New York, United States, 10029
    recruiting status
    Recruiting
    Site Info

    Indago Research & Health Center, Inc

    Hialeah, Florida, United States, 33012
    recruiting status
    Recruiting
    Site Info

    J. Lewis Research, Inc. / Foothill Family Clinic South

    Salt Lake City, Utah, United States, 84121
    recruiting status
    Recruiting
    Site Info

    Kaiser Permanente - San Diego Medical Center

    San Diego, California, United States, 92123
    recruiting status
    Recruiting
    Site Info

    Kaiser Permanente Center for Health Research

    Portland, Oregon, United States, 97227
    recruiting status
    Recruiting
    Site Info

    Kaiser Permanente Daly City

    Daly City, California, United States, 94015
    recruiting status
    Recruiting
    Site Info

    Kaiser Permanente Los Angeles Medical Center

    Los Angeles, California, United States, 90027
    recruiting status
    Recruiting
    Site Info

    Kaiser Permanente Oncology Pharmacy #014C

    Los Angeles, California, United States, 90027
    recruiting status
    Recruiting
    Site Info

    Kaiser Permanente Ontario Medical Center

    Ontario, California, United States, 91761
    recruiting status
    Recruiting
    Site Info

    Kaiser Permanente Roseville

    Roseville, California, United States, 95661
    recruiting status
    Recruiting
    Site Info

    Kaiser Permanente Sacramento

    Sacramento, California, United States, 95815
    recruiting status
    Recruiting
    Site Info

    Kaiser Permanente San Jose

    San Jose, California, United States, 95119
    recruiting status
    Recruiting
    Site Info

    Kaiser Permanente Santa Clara

    Santa Clara, California, United States, 95051
    recruiting status
    Recruiting
    Site Info

    Kaiser Permanente South Sacramento

    Sacramento, California, United States, 95823
    recruiting status
    Recruiting
    Site Info

    Kaiser Permanente Viewridge Medical Office

    San Diego, California, United States, 92123
    recruiting status
    Recruiting
    Site Info

    Kaiser Permanente Walnut Creek

    Walnut Creek, California, United States, 94596
    recruiting status
    Recruiting
    Site Info

    KeyPoint Clinical Research

    Dallas, Texas, United States, 75240
    recruiting status
    Recruiting
    Site Info

    Lakeview Clinical Research

    Guntersville, Alabama, United States, 35976
    recruiting status
    Recruiting
    Site Info

    M3 Wake Research - Lake City

    Lake City, Florida, United States, 32055
    recruiting status
    Recruiting
    Site Info

    McFarland Clinic, PC

    Ames, Iowa, United States, 50010
    recruiting status
    Recruiting
    Site Info

    Med Partners, Inc. dba Premiere Medical Center of Burbank, Inc.

    Toluca Lake, California, United States, 91602
    recruiting status
    Recruiting
    Site Info

    Medical Affiliated Research Center

    Huntsville, Alabama, United States, 35801
    recruiting status
    Recruiting
    Site Info

    Medication Management

    Greensboro, North Carolina, United States, 27405
    recruiting status
    Recruiting
    Site Info

    Mercury Clinical Research - Santa Clara Family Clinic

    Houston, Texas, United States, 77087
    recruiting status
    Recruiting
    Site Info

    Montefiore Medical Center

    The Bronx, New York, United States, 10467
    recruiting status
    Recruiting
    Site Info

    Mount Sinai Morningside

    New York, New York, United States, 10025
    recruiting status
    Recruiting
    Site Info

    Mount Sinai Queens

    Long Island City, New York, United States, 11102
    recruiting status
    Recruiting
    Site Info

    Mount Sinai West

    New York, New York, United States, 10019
    recruiting status
    Recruiting
    Site Info

    NYU Langone Health

    Brooklyn, New York, United States, 11220
    recruiting status
    Recruiting
    Site Info

    NYU Langone Health

    Mineola, New York, United States, 11501
    recruiting status
    Recruiting
    Site Info

    NYU Langone Health

    New York, New York, United States, 10016
    recruiting status
    Recruiting
    Site Info

    New Phase Research and Development

    Knoxville, Tennessee, United States, 37909
    recruiting status
    Recruiting
    Site Info

    North Alabama Research Center

    Athens, Alabama, United States, 35611
    recruiting status
    Recruiting
    Site Info

    North Shore University Hospital

    Manhasset, New York, United States, 11030
    recruiting status
    Recruiting
    Site Info

    North Texas Infectious Diseases Consultants, P.A

    Dallas, Texas, United States, 75246
    recruiting status
    Recruiting
    Site Info

    Northern Westchester Hospital

    Mount Kisco, New York, United States, 10549
    recruiting status
    Recruiting
    Site Info

    Northwell Health Infectious Disease

    Manhasset, New York, United States, 11030
    recruiting status
    Recruiting
    Site Info

    Northwest Houston Heart Center

    Tomball, Texas, United States, 77375
    recruiting status
    Recruiting
    Site Info

    Phelps Hospital Geriatric Medicine & Improvement Science

    Sleepy Hollow, New York, United States, 10591
    recruiting status
    Recruiting
    Site Info

    Proactive Clinical Research,LLC

    Fort Lauderdale, Florida, United States, 33308
    recruiting status
    Recruiting
    Site Info

    Renown Center for Advanced Medicine

    Reno, Nevada, United States, 89502
    recruiting status
    Recruiting
    Site Info

    Renown Regional Medical Center

    Reno, Nevada, United States, 89502
    recruiting status
    Recruiting
    Site Info

    Revive Research Institute, Inc.

    Southfield, Michigan, United States, 48075
    recruiting status
    Recruiting
    Site Info

    Rochester Clinical Research, LLC

    Rochester, New York, United States, 14609
    recruiting status
    Recruiting
    Site Info

    Sanatorio Sagrado Corazón

    Buenos Aires, Argentina, 1039
    recruiting status
    Recruiting
    Site Info

    South Florida Research Organization

    Medley, Florida, United States, 33166
    recruiting status
    Recruiting
    Site Info

    South Jersey Infectious Disease

    Somers Point, New Jersey, United States, 08244
    recruiting status
    Recruiting
    Site Info

    Sundance Clinical Research

    St Louis, Missouri, United States, 63141
    recruiting status
    Recruiting
    Site Info

    The GW Medical Faculty Associates

    Washington D.C., District of Columbia, United States, 20037
    recruiting status
    Recruiting
    Site Info

    The Hope Clinic of Emory University

    Decatur, Georgia, United States, 30030
    recruiting status
    Recruiting
    Site Info

    Trial Management Associates

    Myrtle Beach, South Carolina, United States, 29572
    recruiting status
    Recruiting
    Site Info

    Trial Management Associates, LLC

    Myrtle Beach, South Carolina, United States, 29572
    recruiting status
    Recruiting
    Site Info

    University Health

    Reno, Nevada, United States, 89519
    recruiting status
    Recruiting
    Site Info

    University of Washington - Harborview Medical Center

    Seattle, Washington, United States, 98104
    recruiting status
    Recruiting
    Site Info

    Upstate Global Health Institute

    East Syracuse, New York, United States, 13057
    recruiting status
    Recruiting
    Site Info

    VA Northeast Ohio Healthcare System Louis Stokes Cleveland VA Medical Center

    Cleveland, Ohio, United States, 44106
    recruiting status
    Recruiting
    Site Info

    Velocity Clinical Research, Grand Island

    Grand Island, Nebraska, United States, 68803
    recruiting status
    Recruiting
    Site Info

    Velocity Clinical Research, Omaha

    Omaha, Nebraska, United States, 68134
    recruiting status
    Recruiting
    Site Info

    Velocity Clinical Research, San Bernardino

    San Bernardino, California, United States, 92408
    recruiting status
    Recruiting
    Site Info

    Velocity Clinical Research, Savannah

    Savannah, Georgia, United States, 31406
    recruiting status
    Recruiting
    Site Info

    Velocity Clinical Research, Sioux City

    Sioux City, Iowa, United States, 51106
    recruiting status
    Recruiting
    Site Info

    Velocity Clinical Research, Spartanburg

    Spartanburg, South Carolina, United States, 29303
    recruiting status
    Recruiting
    Site Info

    Wake Forest Baptist Health

    Winston-Salem, North Carolina, United States, 27157
    recruiting status
    Recruiting
    Site Info

    Walker Family Care

    Little River, South Carolina, United States, 29566
    recruiting status
    Recruiting
    Site Info

    Washington University School of Medicine

    St Louis, Missouri, United States, 63110
    recruiting status
    Recruiting
    Site Info

    Bay Pines VA Healthcare System

    Bay Pines, Florida, United States, 33744
    not yet recruiting status
    Not yet recruiting
    Site Info

    CDC Centro Médico

    Lujan de Cuyo, Mendoza Province, Argentina, 5505
    not yet recruiting status
    Not yet recruiting
    Site Info

    Clinical Research Partners, LLC

    Richmond, Virginia, United States, 23226
    not yet recruiting status
    Not yet recruiting
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    Columbia University Irving Medical Center

    New York, New York, United States, 10032
    not yet recruiting status
    Not yet recruiting
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    Emory Steiner Building Research Center

    Atlanta, Georgia, United States, 30303
    not yet recruiting status
    Not yet recruiting
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    Emory University Woodruff Extension Building (WEB)

    Atlanta, Georgia, United States, 30303
    not yet recruiting status
    Not yet recruiting
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    Innovation Medical Research Center

    Palmetto Bay, Florida, United States, 33157
    not yet recruiting status
    Not yet recruiting
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    Investigaciones Clínicas Salta (ICSAL)

    Salta, Argentina, A4400
    not yet recruiting status
    Not yet recruiting
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    Johns Hopkins Bloomberg School of Public Health

    Baltimore, Maryland, United States, 21205
    not yet recruiting status
    Not yet recruiting
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    Kaiser Permanente Oakland

    Oakland, California, United States, 94611
    not yet recruiting status
    Not yet recruiting
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    Kaiser Permanente Washington Health Research Institute (KPWHRI)

    Seattle, Washington, United States, 98101
    not yet recruiting status
    Not yet recruiting
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    Memorial Hermann Hospital - TMC

    Houston, Texas, United States, 77030
    not yet recruiting status
    Not yet recruiting
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    Ochsner Clinic Foundation - Kenner Clinical Trials Unit

    Kenner, Louisiana, United States, 70065
    not yet recruiting status
    Not yet recruiting
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    Ochsner Lafayette General Medical Center

    Lafayette, Louisiana, United States, 70503
    not yet recruiting status
    Not yet recruiting
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    Ochsner Medical Complex - The Grove

    Baton Rouge, Louisiana, United States, 70836
    not yet recruiting status
    Not yet recruiting
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    Palm Springs Community Health Center

    Miami Lakes, Florida, United States, 33014
    not yet recruiting status
    Not yet recruiting
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    Providence Regional Medical Center Everett

    Everett, Washington, United States, 98201
    not yet recruiting status
    Not yet recruiting
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    Rutgers Robert Wood Johnson Medical School

    New Brunswick, New Jersey, United States, 08901
    not yet recruiting status
    Not yet recruiting
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    Sacramento VA Medical Center

    Mather, California, United States, 95655
    not yet recruiting status
    Not yet recruiting
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    The University of Texas Health Science Center at Houston

    Houston, Texas, United States, 77030
    not yet recruiting status
    Not yet recruiting
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    The University of Vermont Medical Center Inc.

    Burlington, Vermont, United States, 05401
    not yet recruiting status
    Not yet recruiting
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    The Vanderbilt Vaccine Research Program Clinic at The Village at Vanderbilt

    Nashville, Tennessee, United States, 37212
    not yet recruiting status
    Not yet recruiting
    Site Info

    UT Physicians

    Houston, Texas, United States, 77030
    not yet recruiting status
    Not yet recruiting
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    UVM Larner College of Medicine MMG/VCT

    Burlington, Vermont, United States, 05401
    not yet recruiting status
    Not yet recruiting
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    University Of Nebraska Medical Center

    Omaha, Nebraska, United States, 68198
    not yet recruiting status
    Not yet recruiting
    Site Info

    University of Nebraska Medical Center

    Omaha, Nebraska, United States, 68105
    not yet recruiting status
    Not yet recruiting
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    Vanderbilt Investigational Drug Service (IDS)

    Nashville, Tennessee, United States, 37232
    not yet recruiting status
    Not yet recruiting
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    Vanderbilt University Medical Center

    Nashville, Tennessee, United States, 37232
    not yet recruiting status
    Not yet recruiting
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    Vanderbilt Vaccine Research Program

    Nashville, Tennessee, United States, 37232
    not yet recruiting status
    Not yet recruiting
    Site Info

    Vanderbilt Vaccine Research Program Laboratory

    Nashville, Tennessee, United States, 37232
    not yet recruiting status
    Not yet recruiting
    Site Info
    • Recruitment Status
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    • Clinical Trials ID

    Study Locations

    View locations for this studyFind the closest location, your results will be shown belowFind the closest location