Learn more about our clinical trials for people living with severe asthma.
Despite recent advances in treatment options, it can still be challenging to control asthma symptoms like shortness of breath, coughing, and wheezing. That’s why we’re researching another potential option.
These clinical trials will help us learn if a potential medicine is safe and can help better control severe asthma symptoms.
The study medicine is designed to target 3 parts of the immune system linked to inflammation in asthma, which may help to better control symptoms.
Participating in these studies
These clinical trials may be an option for people who:
- Are 18 to 80 years of age
- Have had persistent, severe asthma for at least 1 year
- Have had at least 2 asthma attacks (or “flare-ups”) within the last year that required taking steroids (pills or injection) for at least 3 days, an emergency room or urgent care visit (<24 hours) due to asthma and also required use of systemic corticosteroids, or in-patient hospitalization for at least 24 hours
- Have used a combination inhaler for at least 1 year, and have been on a stable dose for at least 3 months
There are other requirements that the study team will discuss with you.
Condition
Persistent, severe asthma
Age
18-80 years
Treatment history
Use of a combination inhaler for at least 1 year, and have been on a stable dose for at least 3 months
This information is a summary of the eligibility criteria across the studies in this program. Each study will have its own unique requirements for who may participate (eligibility criteria). To learn more about the requirements for a study that is actively recruiting, visit the study’s webpage below. Only the research study staff can determine if you qualify to enroll in the study.
Asthma clinical trials
Researching a potential new medicine that may help people [12/18 ]and older living with severe, uncontrolled asthma, to learn if it can help provide better control of asthma symptoms.
Researching a potential new medicine that may help people [12/18 ] and older living with severe, uncontrolled asthma, to learn if it can help provide better control of asthma symptoms.
About the study medicine
The study medicine is a trispecific biologic, a medicine made from living cells. It's designed to block 3 signals in the immune system that may contribute to inflammation associated with severe asthma.
Most asthma biologics target only 1 signal. By targeting 3 signals at the same time, researchers hope to learn whether the study medicine can help reduce asthma flare-ups and improve asthma control.
You can make a difference
Participation by people of all backgrounds is critical to advancing treatment options for asthma. The greater the representation among clinical trial participants, the more we learn about the study medicine and how it works for different people. Including people from all backgrounds helps us develop potential treatments that are more likely to be effective for everyone.
Frequently asked questions
We’re studying a medicine that may help people better manage symptoms of severe asthma. We hope to learn whether targeting three sources of inflammation at once may provide more complete relief for people who haven’t found lasting relief with existing treatments.
Biologic medicines are a type of treatment derived from living cells. They are designed to target specific parts of the immune system and are typically given as injections. The study medicine in this program is investigational, which means it is still being tested and has not yet been approved by regulatory authorities.
A Tri-Specific is a potential new type of biologic medicine being studied. Unlike most advanced biologic treatments, which target one or two proteins in the immune system, a Tri-Specific is designed to target three at the same time. The study medicine in this program is thought to target three specific proteins — IL-4, IL-13, and TSLP — believed to drive the inflammation behind conditions like eczema, asthma, and COPD.
- You will receive care from a team of dedicated specialists
- You will gain access to the latest research and may help advance the future of asthma treatments
- All clinical trial-related care and the study medicine will be provided at no cost
All clinical trials have possible risks. The known risks of taking part in these clinical trials will be explained to you during an informed consent process. This happens before you decide whether to participate.
A lot of information on the study medicine has been collected during previous clinical trials. By participating in one of these clinical trials, you’ll help researchers gather more information to better understand how well the study medicine may work in people living with severe asthma. Researchers will also gain a greater understanding of the side effects that may occur.
