Advancing potential treatment options for melanoma

Learn about Pfizer’s clinical research that is focused on melanoma, a form of skin cancer.

Despite recent advances in the treatment of melanoma, more options are needed. Pfizer is currently conducting a clinical trial that is looking at whether three study drugs are safe and effective when given together for melanoma that:

  • is advanced or metastatic (spread to other parts of the body);
  • has a certain type of abnormal gene called “BRAF”

About half of people with metastatic melanoma have the BRAF gene, which causes cancer cells to multiply out of control. Identifying whether a person with melanoma has the BRAF gene is an important way to identify an appropriate treatment.

If you or a loved one are considering taking part in a melanoma clinical trial, find more information below. With your participation, clinical research might help to identify better treatment options for people with melanoma.

Find a melanoma clinical trial

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Melanoma
A Clinical Trial of Three Study Medicines (Encorafenib, Binimetinib, and Pembrolizumab) in Patients With Advanced or Metastatic Melanoma
NCT04657991
Recruiting
Male or Female
18+ years
330study location(s)
Melanoma, Colorectal Cancer, Non-Small-Cell Lung Cancer, Thyroid Cancer, Glioma
A Study to Learn About the Study Medicine Called PF-07799933 in People With Advanced Solid Tumors.
NCT05355701
Recruiting
Male or Female
16+ years
48study location(s)
Malignant Melanoma, Carcinoma, Non-Small-Cell Lung, Brain Neoplasms, Primary, Brain Neoplasms, Malignant Neoplasms
A FIH Study of PF-07284890 in Participants With BRAF V600 Mutant Solid Tumors With and Without Brain Involvement
NCT04543188
Recruiting
Male or Female
16+ years
140study location(s)
Melanoma, Glioma, Thyroid Cancer, Non-Small Cell Lung Cancer, Malignant Neoplasms, Brain Neoplasms, Colorectal Cancer
A Study to Learn About the Study Medicine Called PF-07799544 in People With Advanced Solid Tumors
NCT05538130
Recruiting
Male or Female
16+ years
3study location(s)
Melanoma
Comparative Effectiveness of Targeted Therapies in BRAF Positive Metastatic Melanoma in the US
NCT05260684
Recruiting
Male or Female
18-100years
1study location(s)

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Contact us

For more information about participation in a Pfizer clinical trial, please email or call the Pfizer Clinical Trial Contact Center at 1-800-887-7002.

About melanoma

Melanoma is a type of skin cancer that begins in the cells that give the skin its color, called melanocytes. Advanced or metastatic melanoma is a serious form of skin cancer that has spread to other parts of the body.

Skin cancers start to form when skin cells are damaged by UV radiation from the sun or tanning beds, causing certain DNA (genes) to become abnormal. About half of people with metastatic melanoma have an abnormal gene called BRAF that causes cancer cells to multiply out of control.

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