Learn about Pfizer’s clinical research that is focused on melanoma, a form of skin cancer.

Despite recent advances in the treatment of melanoma, more options are needed. Pfizer is currently conducting a clinical trial that is looking at whether three study drugs are safe and effective when given together for melanoma that:

  • is advanced or metastatic (spread to other parts of the body);
  • has a certain type of abnormal gene called “BRAF”

About half of people with metastatic melanoma have the BRAF gene, which causes cancer cells to multiply out of control. Identifying whether a person with melanoma has the BRAF gene is an important way to identify an appropriate treatment.

If you or a loved one are considering taking part in a melanoma clinical trial, find more information below. With your participation, clinical research might help to identify better treatment options for people with melanoma.

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      7 trials found

      All(7)
      Recruiting(7)
      Not yet recruiting(0)
      Recruiting
      NCT05355701
      A Study to Learn About the Study Medicine Called PF-07799933 in People With Advanced Solid Tumors With BRAF Alterations.

      Melanoma, Non-Small-Cell Lung Cancer, Thyroid Cancer, Glioma

      Male or Female
      16+ years
      84study location(s)
      Recruiting
      NCT05926960
      A Study Comparing 3 Study Medicines (Encorafenib, Binimetinib, Pembrolizumab) to 2 Study Medicines (Ipilimumab and Nivolumab) in Patients With Advanced Melanoma

      Melanoma

      Male or Female
      18+ years
      58study location(s)
      Recruiting
      NCT04609566
      Brentuximab Vedotin With Pembrolizumab in Metastatic Solid Tumors

      Melanoma, Non-small Cell Lung Cancer, Squamous Cell Carcinoma of the Head and Neck

      Male or Female
      18+ years
      25study location(s)
      Recruiting
      NCT06285097
      A Study of PF-07820435 as a Single Agent and in Combination in Participants With Advanced Solid Tumors

      Neoplasms, Non-small-cell Lung Cancer, Melanoma, Squamous Cell Carcinoma of the Head and Neck, Renal Cell Carcinoma, Urothelial Carcinoma, Colorectal Carcinoma, Ovarian Carcinoma

      Male or Female
      18+ years
      12study location(s)
      Recruiting
      NCT05538130
      A Study to Learn About the Study Medicine Called PF-07799544 in People With Advanced Solid Tumors

      Melanoma, Glioma, Thyroid Cancer, Non-Small Cell Lung Cancer, Malignant Neoplasms, Brain Neoplasms, Colorectal Cancer

      Male or Female
      16+ years
      58study location(s)
      Recruiting
      NCT05208762
      A Study of SGN-PDL1V in Advanced Solid Tumors

      Carcinoma, Non-Small-Cell Lung, Squamous Cell Carcinoma of the Head and Neck, Esophageal Squamous Cell Carcinoma, Ovarian Neoplasms, Melanoma, Triple Negative Breast Neoplasms, Gastric Cancer

      Male or Female
      18+ years
      23study location(s)
      Recruiting
      NCT05571839
      A Study of SGN-BB228 in Advanced Melanoma and Other Solid Tumors

      Cutaneous Melanoma, Non-small Cell Lung Cancer, Colorectal Neoplasms, Pancreatic Neoplasms, Mesothelioma

      Male or Female
      18+ years
      18study location(s)

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      All(7)
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      Contact us

      For more information about participation in a Pfizer clinical trial, please email or call the Pfizer Clinical Trial Contact Center at 1-800-887-7002.


      About melanoma

      Melanoma is a type of skin cancer that begins in the cells that give the skin its color, called melanocytes. Advanced or metastatic melanoma is a serious form of skin cancer that has spread to other parts of the body.

      Skin cancers start to form when skin cells are damaged by UV radiation from the sun or tanning beds, causing certain DNA (genes) to become abnormal. About half of people with metastatic melanoma have an abnormal gene called BRAF that causes cancer cells to multiply out of control.