Advancing potential colorectal (colon) cancer treatment options

Learn about Pfizer’s clinical research into a potential targeted therapy for colorectal cancer.

Colorectal cancer, also called colon cancer, is the second leading cause of cancer death in the United States. Pfizer is currently conducting a clinical trial with a focus on colorectal cancer that:

  • is advanced or metastatic (spread to other parts of the body);
  • has a certain type of abnormal gene called “BRAF”

About 10 to 15 percent of people with colorectal cancer have the abnormal BRAF gene, which causes cancer cells to multiply out of control. Identifying whether a person with colorectal cancer has the BRAF gene is an important way to identify an appropriate treatment.

In addition to conducting a clinical trial focused on BRAF-positive colorectal cancer, we are also evaluating other approaches and potential treatments.

If you or a loved one are considering taking part in a colorectal cancer clinical trial, find more information below. With your participation, clinical research might help to identify better treatment options for people with colorectal cancer.

Find a colorectal (colon) cancer clinical trial

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9 trials found
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Metastatic Colorectal Cancer
A Study of Encorafenib Plus Cetuximab Taken Together With Pembrolizumab Compared to Pembrolizumab Alone in People With Previously Untreated Metastatic Colorectal Cancer
NCT05217446
Recruiting
Male or Female
16+ years
198study location(s)
Neoplasms
A Study of Encorafenib Plus Cetuximab With or Without Chemotherapy in People With Previously Untreated Metastatic Colorectal Cancer
NCT04607421
Recruiting
Male or Female
16+ years
760study location(s)
Melanoma, Colorectal Cancer, Non-Small-Cell Lung Cancer, Thyroid Cancer, Glioma
A Study to Learn About the Study Medicine Called PF-07799933 in People With Advanced Solid Tumors.
NCT05355701
Recruiting
Male or Female
16+ years
50study location(s)
Non-small Cell Lung Cancer, Pancreatic Cancer, Colorectal Cancer, Loss of Appetite, Fatigue, Cachexia
Study of the Efficacy and Safety of Ponsegromab in Patients With Cancer, Cachexia and Elevated GDF-15
NCT05546476
Recruiting
Male or Female
18+ years
150study location(s)
Melanoma, Glioma, Thyroid Cancer, Non-Small Cell Lung Cancer, Malignant Neoplasms, Brain Neoplasms, Colorectal Cancer
A Study to Learn About the Study Medicine Called PF-07799544 in People With Advanced Solid Tumors
NCT05538130
Recruiting
Male or Female
16+ years
16study location(s)
Gastrointestinal Tumors, Colorectal Adenocarcinomas, Gastric Adenocarcinomas, Esophageal Adenocarcinomas
Study to Test the Safety and Tolerability of PF-07062119 in Patients With Selected Advanced or Metastatic Gastrointestinal Tumors.
NCT04171141
Recruiting
Male or Female
18+ years
38study location(s)
Solid Tumor
PF-07284892 in Participants With Advanced Solid Tumors
NCT04800822
Recruiting
Male or Female
18+ years
14study location(s)
Metastatic Colorectal Cancer
ZN-c3 in Adult Participants With Metastatic Colorectal Cancer
NCT05743036
Recruiting
Male or Female
18+ years
2study location(s)
Non-small Cell Lung Cancer, Metastatic Colorectal Cancer, Metastatic Breast Cancer, Metastatic Kidney Cancer, Cervical Cancer, Epithelial Ovarian Cancer, Fallopian Tube Cancer, Primary Peritoneal Cancer
A Post-marketing Surveillance to Assess the Safety and Effectiveness of Zirabev in Domestic Patients With Various Cancer
NCT04889495
May 31, 2023 - Planned start date (Not yet recruiting)
Male or Female
19+ years
1study location(s)

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Contact us

For more information about participation in a Pfizer clinical trial, please email or call the Pfizer Clinical Trial Contact Center at 1-800-887-7002.

About colorectal cancer

Colorectal cancer, also known as colon cancer, occurs when tumors form in the lining of the large intestine. The risk of developing colorectal cancer increases after age 50. Colorectal cancer is common in both men and women.

In addition to age, risk factors include having a family history of colorectal cancer, having ulcerative colitis or Crohn’s disease, eating a diet high in fat, or smoking.

Colorectal cancer symptoms include diarrhea or constipation, a feeling that the bowel does not empty completely, blood in the stool, or frequent gas pains or cramps. There may be no symptoms initially, which is why it is important to have colorectal cancer screening tests.

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