Learn about Pfizer’s clinical research into a potential targeted therapy for colorectal cancer.

Colorectal cancer, also called colon cancer, is the second leading cause of cancer death in the United States. Pfizer is currently conducting a clinical trial with a focus on colorectal cancer that:

  • is advanced or metastatic (spread to other parts of the body);
  • has a certain type of abnormal gene called “BRAF”

About 10 to 15 percent of people with colorectal cancer have the abnormal BRAF gene, which causes cancer cells to multiply out of control. Identifying whether a person with colorectal cancer has the BRAF gene is an important way to identify an appropriate treatment.

In addition to conducting a clinical trial focused on BRAF-positive colorectal cancer, we are also evaluating other approaches and potential treatments.

If you or a loved one are considering taking part in a colorectal cancer clinical trial, find more information below. With your participation, clinical research might help to identify better treatment options for people with colorectal cancer.

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      6 trials found

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      Recruiting(5)
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      Recruiting
      NCT05355701
      A Study to Learn About the Study Medicine Called PF-07799933 in People With Advanced Solid Tumors.

      Melanoma, Colorectal Cancer, Non-Small-Cell Lung Cancer, Thyroid Cancer, Glioma

      Male or Female
      16+ years
      76study location(s)
      Recruiting
      NCT05217446
      A Study of Encorafenib Plus Cetuximab Taken Together With Pembrolizumab Compared to Pembrolizumab Alone in People With Previously Untreated Metastatic Colorectal Cancer

      Metastatic Colorectal Cancer

      Male or Female
      16+ years
      204study location(s)
      Recruiting
      NCT04607421
      A Study of Encorafenib Plus Cetuximab With or Without Chemotherapy in People With Previously Untreated Metastatic Colorectal Cancer

      Neoplasms

      Male or Female
      16+ years
      780study location(s)
      Recruiting
      NCT05538130
      A Study to Learn About the Study Medicine Called PF-07799544 in People With Advanced Solid Tumors

      Melanoma, Glioma, Thyroid Cancer, Non-Small Cell Lung Cancer, Malignant Neoplasms, Brain Neoplasms, Colorectal Cancer

      Male or Female
      16+ years
      48study location(s)
      Recruiting
      NCT04171141
      Study to Test the Safety and Tolerability of PF-07062119 in Patients With Selected Advanced or Metastatic Gastrointestinal Tumors.

      Gastrointestinal Tumors, Colorectal Adenocarcinomas, Gastric Adenocarcinomas, Esophageal Adenocarcinomas

      Male or Female
      18+ years
      38study location(s)
      Sep 01, 2024 - Planned start date (Not yet recruiting)
      NCT04889495
      A Post-marketing Surveillance to Assess the Safety and Effectiveness of Zirabev in Domestic Patients With Various Cancer

      Non-small Cell Lung Cancer, Metastatic Colorectal Cancer, Metastatic Breast Cancer, Metastatic Kidney Cancer, Cervical Cancer, Epithelial Ovarian Cancer, Fallopian Tube Cancer, Primary Peritoneal Cancer

      Male or Female
      19+ years
      1study location(s)

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      All(6)
      Recruiting(5)
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      Contact us

      For more information about participation in a Pfizer clinical trial, please email or call the Pfizer Clinical Trial Contact Center at 1-800-887-7002.


      About colorectal cancer

      Colorectal cancer, also known as colon cancer, occurs when tumors form in the lining of the large intestine. The risk of developing colorectal cancer increases after age 50. Colorectal cancer is common in both men and women.

      In addition to age, risk factors include having a family history of colorectal cancer, having ulcerative colitis or Crohn’s disease, eating a diet high in fat, or smoking.

      Colorectal cancer symptoms include diarrhea or constipation, a feeling that the bowel does not empty completely, blood in the stool, or frequent gas pains or cramps. There may be no symptoms initially, which is why it is important to have colorectal cancer screening tests.