Clinical Trial for Overweight, Obesity and Healthy Adults.

Who may participate

Each clinical study has its own guidelines for who may participate, called eligibility criteria. These factors can include your age, sex, overall health, type and stage of disease, and personal treatment history. However, only the research study staff can determine if you qualify to enroll in the study.

Condition

Overweight, Obesity, Healthy Adults

Sex

Male or Female

Age

18+ years

Healthy participants

Yes

Visit ClinicalTrials.gov for more information

Eligibility criteria

Inclusion criteria

Participants 18 years of age or older at screening who are overtly healthy as determined by medical evaluation including medical history, physical examination, laboratory tests, and ECGs.
BMI of 24-45 kg/m2; and a total body weight >50 kg (110 lb).
Chinese participants are defined as individuals currently residing in mainland China who were born in China and have both parents of Chinese descent.

Exclusion criteria

Pregnant or breastfeeding women, or those planning pregnancy during the study.
Clinically significant medical conditions including hematologic, renal, endocrine, pulmonary, gastrointestinal (including pancreatitis, gallbladder disease, clinically relevant gastric emptying disorders), cardiovascular, hepatic, psychiatric, neurologic, or severe allergic diseases.
Personal or first-degree family history of medullary thyroid carcinoma (MTC) or multiple endocrine neoplasia type 2 (MEN2), or suspected MTC.
Active or recent suicidal ideation in the past year, suicidal behavior within the past 5 years, or any psychiatric condition that increases risk in the investigator's judgment.
Clinically significant gastric emptying abnormality or chronically taking drugs that directly affect GI motility.
Acute gastrointestinal symptoms at screening or Day -1.
Known hypersensitivity to PF-08653944, GLP-1 receptor agonists, or any excipients.
Prior participation in any study involving PF-08653944 with at least one dose received.

Study overview

The purpose of this study is to learn about:

How PF-08653944 is changed and removed from the body after taken
Safety of PF-08653944
The extent to which side effects can be tolerated after taking PF- 08653944 for the possible treatment of heart failure

This study is seeking participants who:

Are healthy Chinese adults who are aged 18 years and older
Have body mass index of 24 - 45 kilograms/meter2
Have a total body weight of equal to or more than 50 kilograms (110 pounds)
Do not have prior significant medical conditions, history of drug or alcohol abuse

All participants in this study will receive a single dose of PF-08653944 at the study clinic.

The experiences of the participants receiving the study medicine will be looked at. This will help to see if the study medicine is safe.

Participants will take part in this study for around 16 weeks. During this time, they will have 6 study visits at the study clinic.

Join PfizerConnect

A Study to Learn About the Study Medicine Called PF-08653944 in Otherwise Healthy Chinese Adults With Overweight or Obesity

Who may participate

Eligibility criteria

Study overview

View locations for this study

Nearest Locations found

Join PfizerConnect

A Study to Learn About the Study Medicine Called PF-08653944 in Otherwise Healthy Chinese Adults With Overweight or Obesity

Who may participate

Eligibility criteria

Study overview

View locations for this study

Nearest Locations found

Are you a Healthcare Professional?