Clinical Trial for Asthma.

Who may participate

Each clinical study has its own guidelines for who may participate, called eligibility criteria. These factors can include your age, sex, overall health, type and stage of disease, and personal treatment history. However, only the research study staff can determine if you qualify to enroll in the study.

Condition

Asthma

Sex

Male or Female

Age

18 - 70 years

Healthy participants

Visit ClinicalTrials.gov for more information

Eligibility criteria

Inclusion and Exclusion

Inclusion Criteria:

Must meet the following asthma criteria:

History of persistent, moderate-to-severe asthma for at least 12 months prior to screening.
Must have experienced at least 1 asthma exacerbation requiring treatment with systemic steroids (oral or parenteral) for 3 days or more within 12 months of the screening visit.
At least 2 of the 3 pre-bronchodilator FEV1 values collected in the run-in period and the mean of the of pre-bronchodilator FEV1 values collected in the run-in period are ≥30% to <80% of predicted normal values.
Positive bronchodilator responsiveness as evidenced by increase in FEV1 of at least 12% and 200 mL for spirometry conducted during screening period.
Maintenance (controller) treatment that minimally includes a medium to high dose ICS - LABA combination consistent with GINA Step 4/5 (either Track 1 or Track 2) for 12 months prior to the screening visit and at a stable dose for at least 3 months prior to the screening visit.
ACQ-5 score of ≥1.5 at screening visit and prior to randomization.

Other Inclusion Criteria:

Body mass index between 18 40 kg/m2 at screening.

Exclusion Criteria:

Medical Conditions:

Any medical or psychiatric condition including recent (within the past year) or active suicidal ideation/behavior or laboratory abnormality that may increase the risk of study participation or, in the investigator's judgment, make the participant inappropriate for the study.
Evidence of lung disease(s) other than asthma, either clinical evidence, spirometry, or imaging (Chest X-ray, CT, MRI) within 12 months of the screening visit, as per local standard of care, including but not limited to: Chronic obstructive pulmonary disease, Other emphysematous lung disease such as alpha-1 antitrypsin disease, Cystic fibrosis, Emphysema, Idiopathic pulmonary fibrosis, Churg-Strauss syndrome, Allergic bronchopulmonary aspergillosis, Sarcoidosis
Diagnosed with any of the following acute or chronic infections or infection history:
- Active helminth or parasitic infection requiring treatment within 2 weeks prior to screening;
- Infection requiring hospitalization or systemic (parenteral) antimicrobial therapy within 60 days prior to Day 1;
- Any infection judged to be an opportunistic infection or clinically significant by the investigator, within 6 months prior to Day 1.

Prior/Concomitant Therapy:

Prior or current use of any prohibited concomitant medication(s) or unwillingness or inability to use a required concomitant medication(s).
Prior or concurrent treatment with either approved or experimental biologic treatment (such as inhibitors of IL-4, IL-13, IL-33/ST2, IL-4Rα, TSLP, IL-5, OX40/OX40L or IgE) or targeted synthetic drugs (such as JAK inhibitors) for the treatment of asthma or other type 2 inflammatory diseases, including but not limited to: AD, EoE, CRS.
Treatment with any dose level of systemic (oral, injectable, or intraarticular) corticosteroids within 28 days of the screening visit.
Prior (within 12 weeks prior to screening) or planned concomitant treatment with immunoglobulin supplementation (eg, IV Ig or SC Ig).
History of anaphylaxis to antibody therapeutic or to PF-07275315 or to the excipients of the formulated drug products.
Bronchial thermoplasty within the previous 24 months.

Prior/Concurrent Clinical Study Experience:

Administration of an investigational drug product within 30 days or 5 half lives preceding the screening visit (whichever is longer). Participation in studies of other investigational products (drug or vaccine) at any time during participation in this study.

Study overview

The purpose of this clinical trial is to learn about the safety and effects of the study medicine (called PF-07275315) for the potential treatment of moderate-to-severe asthma. Asthma is a condition that makes it challenging to breathe, which negatively impacts the quality of life and functioning of people who are affected.

This study is seeking participants who:

Are 18 to 70 years old
Have had moderate-to-severe asthma for at least 12 months that is not well controlled
Have been taking their regular maintenance treatment(s) for asthma over the last 12 months

All participants will receive PF-07275315 or a placebo. A placebo does not have any medicine in it but looks just like the medicine being studied.

PF-07275315 or placebo will be given as multiple shots in the clinic over the course of 12 weeks. We will compare the experiences of people receiving PF-07275315 to those of the people who do not. This will help us determine if PF-07275315 is safe and effective.

Participants will be involved in this study for about 7.5 months. During this time, they will have 9 visits at the study clinic.

View locations for this study

Find the closest location, your results will be shown below

Find the closest location

Miles

0500

Nearest Locations found

125 sites found

ALERGO-MED OŚRODEK BADAŃ KLINICZNYCH Sp. z o.o.

Tarnów, Lesser Poland Voivodeship, Poland, 33-100

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AZ Sint-Maarten

Mechelen, Antwerpen, Belgium, 2800

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Addenbrooke's Hospital

Cambridge, Cambridgeshire, United Kingdom, CB2 2QQ

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Alergologia Plus sp. z o.o.

Poznan, Greater Poland Voivodeship, Poland, 60-693

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Alina Clinical Trials, LLC.

Dallas, Texas, United States, 75209

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Allergy & Asthma Clinical Research

Walnut Creek, California, United States, 94598

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Allergy and Asthma Associates of Santa Clara Valley Research Center

San Jose, California, United States, 95117

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American Health Research

Charlotte, North Carolina, United States, 28277

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Antelope Valley Clinical Trials

Lancaster, California, United States, 93534

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Asan Medical Center

Seoul, Seoul-teukbyeolsi [seoul], South Korea, 05505

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Azienda Ospedaliera Ordine Mauriziano di Torino

Torino, Italy, 10128

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Azienda Ospedaliero Universitaria Senese

Siena, Tuscany, Italy, 53100

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Azienda Ospedaliero-Universitaria San Luigi Gonzaga

Orbassano, Piedmont, Italy, 10043

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Beijing Chao-Yang Hospital, Capital Medical University

Beijing, Beijing Municipality, China, 100020

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CEFISPIRO s.r.o.

Lovosice, Czechia, 410 02

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California Medical Research Associates

Northridge, California, United States, 91324

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Chandler Clinical Trials

Chandler, Arizona, United States, 85224

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Chang Gung Medical Foundation-Linkou Branch

Taoyuan District, Taiwan, 333

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Christie Clinic - University

Champaign, Illinois, United States, 61820

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Christie Clinic - Windsor

Champaign, Illinois, United States, 61822

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Circuit Clinical / Impact Medical Allergy, Asthma & Immunology

Riverdale, New Jersey, United States, 07457

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Clinical Research Associates of Central PA, LLC

DuBois, Pennsylvania, United States, 15801

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Clinical Research of Rock Hill

Rock Hill, South Carolina, United States, 29732

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Colorado ENT & Allergy

Colorado Springs, Colorado, United States, 80923

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Da Vinci Magánklinika

Pécs, Hungary, 7635

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Diagnostic Consultative Center Aleksandrovska

Sofia, Sofia (stolitsa), Bulgaria, 1431

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Dobrostan Gabinet Lekarskie

Wroclaw, Lower Silesian Voivodeship, Poland, 53-301

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Erzsebet Gondozohaz

Gödöllő, Pest County, Hungary, 2100

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Fakultni nemocnice Hradec Kralove

Hradec Králové, Czechia, 500 05

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Fukuoka National Hospital

Fukuoka, Japan, 811-1394

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Fukuwa Clinic

Chuo-ku, Tokyo, Japan, 104-0031

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Fundacion Scherbovsky

Mendoza, Argentina, 5500

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Greater Heights & Memorial Pulmonary and Sleep

Houston, Texas, United States, 77008

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Hamamatsu Rosai Hospital

Hamamatsu, Shizuoka, Japan, 430-8525

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Henderson Clinical Trials

Henderson, Nevada, United States, 89052

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Hiroshima Prefectural Hospital

Hiroshima, Japan, 734-0004

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Horizon Clinical Research Group

Cypress, Texas, United States, 77429

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Hospital Universitario La Paz

Madrid, Madrid, Comunidad de, Spain, 28046

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Houston Pulmonary Sleep and Allergy Associates

Houston, Texas, United States, 77065

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IRCCS Istituto Clinico Humanitas

Rozzano, Milano, Italy, 20089

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Inner Mongolia People's Hospital

Hohhot, Inner Mongolia, China, 010017

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Innovo Research - Christie Clinic

Champaign, Illinois, United States, 61820

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Instituto de Salud Respiratoria

Mendoza, Argentina, 5500

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Investigaciones en Patologias Respiratorias

San Miguel de Tucumán, Tucumán Province, Argentina, 4000

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Jeonbuk National University Hospital

Jeonju, Jeonrabugdo, South Korea, 54907

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Jiangxi Provincial People's Hospital

Nanchang, Jiangxi, China, 330006

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KLIMED Marek Klimkiewicz

Bychawa, Lublin Voivodeship, Poland, 18-404

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Kobe City Medical Center West Hospital

Kobe, Hyōgo, Japan, 653-0013

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Koch Róbert Kórház és Rendelőintézet

Edelény, Borsod-Abauj Zemplen county, Hungary, 3780

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Konkuk University Medical Center

Seoul, Seoul-teukbyeolsi [seoul], South Korea, 05030

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Korea University Guro Hospital

Seoul, Seoul-teukbyeolsi [seoul], South Korea, 08308

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Layrek Clinical Research

Tulsa, Oklahoma, United States, 74133

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MEDITRIAL s.r.o.

Jindrichuv Hradec III, Jihočeský kraj, Czechia, 377 01

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Mazda Hospital

Aki-gun Fuchu-cho, Hiroshima, Japan, 735-8585

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Małopolskie Centrum Alergologii

Krakow, Lesser Poland Voivodeship, Poland, 31-624

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Medical Center New Rehabilitation Center EOOD

Stara Zagora, Bulgaria, 6001

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Medical Center Pulmo - 2018 EOOD

Haskovo, Bulgaria, 6300

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Medical Center Pulmovision

Sofia, Bulgaria, 1756

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Metroplex Pulmonary and Sleep Center

McKinney, Texas, United States, 75069

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Mudr.I.Cierna Peterova s.r.o.

Brandýs nad Labem, Central Bohemia, Czechia, 25001

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NHO Kinki Chuo Chest Medical Center

Sakai, Osaka, Japan, 591-8555

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Nanjing First Hospital

Najing, Jiangsu, China, 210001

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National Hospital Organization Osaka Minami Medical Center

Kawachi-Nagano, Osaka, Japan, 586-8521

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NewportNativeMD, Inc.

Newport Beach, California, United States, 92663

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North Manchester General Hospital

Crumpsall, United Kingdom, M8 5RB

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OK Clinical Research

Edmond, Oklahoma, United States, 73034

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Omnimodus Elixír Kft.

Mosonmagyaróvár, Győr-Moson-Sopron, Hungary, 9200

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Outpatients

Cambridge, Cambridgeshire, United Kingdom, cb2 0qq

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PULMAG s.c.

Sosnowiec, Silesian Voivodeship, Poland, 41-208

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Pinderfields General Hospital

Wakefield, United Kingdom, WF1 4DG

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Policlinico Universitario Monserrato

Monserrato, Cagliari, Italy, 09042

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Premier Research Center, LLC

Hendersonville, Tennessee, United States, 37075

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Rutgers, Robert Wood Johnson Medical School

New Brunswick, New Jersey, United States, 08901

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Samsung Medical Center

Seoul, Seoul-teukbyeolsi [seoul], South Korea, 06351

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Severance Hospital, Yonsei University Health System

Seoul, Seoul-teukbyeolsi [seoul], South Korea, 03722

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Shanghai General Hospital

Shanghai, Shanghai Municipality, China, 200080

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South Texas Medical Research Institute, Inc., DBA TTS Research

Boerne, Texas, United States, 78006

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Specjalistyczna Przychodnia Lekarska Alergo-Med Sp. z o.o

Poznan, Greater Poland Voivodeship, Poland, 61-578

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Szalay János Rendelőintézet

Hajdúnánás, Hajdú-Bihar, Hungary, 4080

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The Affiliated Hospital of Inner Mongolia Medical University

Hohhot, Inner Mongolia, China, 010050

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The Affiliated Hospital of Xuzhou Medical College

Xuzhou, Jiangsu, China, 221006

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The Catholic Univ. of Korea Seoul St. Mary's Hospital

Seoul, Seoul-teukbyeolsi [seoul], South Korea, 06591

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The Catholic University of Korea, Eunpyeong St. Mary's Hospital

Seoul, Seoul-teukbyeolsi [seoul], South Korea, 03312

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The First Affiliated Hospital of Xi'an Medical University

Xi'an, Shaanxi, China, 710077

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The Second Hospital of Jilin University

Changchun, Jilin, China, 130000

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The Third Affiliated Hospital of Guangzhou Medical University

Guangzhou, Guangdong, China, 510150

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Tokyo Medical University Hachioji Medical Center

Hachiōji, Tokyo, Japan, 1930998

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Toledo Institute of Clinical Research Inc.

Toledo, Ohio, United States, 43617

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UZ Gent

Ghent, Oost-vlaanderen, Belgium, 9000

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University of Kansas Medical Center

Kansas City, Kansas, United States, 66160

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Velocity Clinical Research, Mobile

Mobile, Alabama, United States, 36608

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Washington University School of Medicine

St Louis, Missouri, United States, 63110

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Wythenshawe Hospital

Manchester, Greater Manchester, United Kingdom, M23 9LT

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Yeungnam Univeristy Medical Center

Daegu, Taegu-kwangyǒkshi, South Korea, 42415

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Yeungnam University hospital

Daegu, Kyǒngsangbuk-do, South Korea, 42415

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Zhejiang Provincial People's Hospital

Hangzhou, Zhejiang, China, 310014

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Allergy, Asthma and Clinical Research

Oklahoma City, Oklahoma, United States, 73120

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Bradford Royal Infirmary

Bradford, United Kingdom, BD9 6RJ

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Centre Hospitalier Régional de la Citadelle

Liège, Belgium, 4000

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Centro de Investigaciones Metabólicas (CINME)

Buenos Aires, Argentina, C1056ABI

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Changhua Christian Hospital

Changhua County, Changhua, Taiwan, 50006

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China-Japan Friendship Hospital

Beijing, Beijing Municipality, China, 100029

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Clinical Research Of Gastonia

Gastonia, North Carolina, United States, 28054

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Clinical Research Partners, LLC

Richmond, Virginia, United States, 23226

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Cpcc-Research Llc

East Point, Georgia, United States, 30344

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Far Eastern Memorial Hospital

New Taipei City, NEW Taipei, Taiwan, 220

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Fujieda Municipal General Hospital

Fujieda, Shizuoka, Japan, 426-8677

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Fundación Respirar

Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina, C1426ABP

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Hammersmith Hospital

London, London, CITY of, United Kingdom, W12 0HS

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Hospital Universitario Quironsalud Madrid

Pozuelo de Alarcón, Madrid, Spain, 28223

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Hospital Universitario Virgen de la Victoria

Málaga, Málaga, Spain, 29010

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Jiangsu Province Hospital

Nanjing, Jiangsu, China, 210029

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Kaohsiung Medical University Chung-Ho Memorial Hospital

Kaohsiung City, Taiwan, 807

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National Taiwan University Hospital

Taipei, Taiwan, 10002

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North Ingalls Building

Ann Arbor, Michigan, United States, 48109

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Ruijin Hospital Shanghai Jiaotong University School of Medicine

Shanghai, Shanghai Municipality, China

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Shanghai Pulmonary Hospital

Shanghai, Shanghai Municipality, China, 200433

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Stern Research Partners, LLC

Huntersville, North Carolina, United States, 28078

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Taichung Veterans General Hospital

Taichung, Taiwan, 407

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Taizhou Central Hospital

Taizhou, Zhejiang, China, 318000

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The First Affiliated Hospital of Baotou Medical College

Baotou, Inner Mongolia, China, 014010

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The First People's Hospital of Hangzhou

Hangzhou, Zhejiang, China

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University of Michigan

Ann Arbor, Michigan, United States, 48109

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West China Hospital, Sichuan University

Chengdu, Sichuan, China, 610041

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Xuzhou Central Hospital

Xuzhou, Jiangsu, China, 221009

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Join PfizerConnect

A Study to Learn About the Study Medicine Called PF-07275315 in People With Moderate-To-Severe Asthma

Who may participate

Eligibility criteria

Study overview

View locations for this study

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Join PfizerConnect

A Study to Learn About the Study Medicine Called PF-07275315 in People With Moderate-To-Severe Asthma

Who may participate

Eligibility criteria

Study overview

View locations for this study

Nearest Locations found

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