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The purpose of this study is to learn if the medicine called itraconazole changes how the body processes another study medicine called PF-07258669 in older adults.
The study medicine PF-07258669 is developed for the treatment of anorexia in older adults. People with this condition have decreased appetite and food intake, which is an important reason for undernutrition and poor health results in people with anorexia.
The study is seeking participants who:
1. Are males or females who can no longer have children.
2. Are at least 65 years old and in reasonably good health.
3. Have a body mass index (BMI) of 16 to 27 kilogram per meter squared and a total body weight of more than 40 kilograms (88 pounds).
Participants will take the study medicine PF-07258669 as tablets by mouth once on Day 1 at the study clinic and stay at the clinic for about 12 days. Then starting on Day 4, participants will take itraconazole as liquid by mouth for eight days. On Day 7, itraconazole will be taken together with PF-07258669. During this time, the study team will observe the participants and take urine and blood samples to look at the levels of PF-07258669. The participants will receive a follow up telephone call about one month later.
Closest Location
NCT# stands for National Clinical Trial number. This is a unique identification code given to each clinical trial registered on ClinicalTrials.gov. The format is "NCT" followed by an 8-digit number (for example, NCT00000419). Also called the ClinicalTrials.gov identifier.
Each clinical study has its own guidelines for who may participate, called eligibility criteria. These factors can include your age, sex, overall health, type and stage of disease, and personal treatment history. However, only the research study staff can determine if you qualify to enroll in the study.
Condition
Healthy
Sex
Male or Female
Age
65+ years