NCT04657991

Simple Title
A Phase 3, Randomized, Double-blind Study of Encorafenib and Binimetinib Plus Pembrolizumab Versus Placebo Plus Pembrolizumab in Participants With BRAF V600E/K Mutation-Positive Metastatic OR Unresectable Locally Advanced Melanoma

Melanoma

Who may participate

Each clinical study has its own guidelines for who may participate, called eligibility criteria. These factors can include your age, sex, overall health, type and stage of disease, and personal treatment history. However, only the research study staff can determine if you qualify to enroll in the study.

Condition

Melanoma

The disease, disorder, syndrome, illness, or injury that is being studied. On ClinicalTrials.gov, conditions may also include other health-related issues, such as lifespan, quality of life, and health risks.
Sex
Male or Female
The sex of people who may participate in a clinical trial (all, female, male). Sex is a person’s classification based on assignment at birth. Eligibility based on sex is distinct from eligibility based on gender.
Age
18+ years
The age a person must be to participate in a clinical trial.
View more eligibility criteria on ClinicalTrials.gov

Study Locations

Study Locations
152 trials found.

Universitaetsklinikum Carl Gustav Carus Dresden

Dresden, Sachsen, Germany, 01307
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AO di Perugia - Ospedale S. Maria della Misericordia, S.C Oncologia Medica

Perugia, Italy, 06132
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CHUAC-Hospital Teresa Herrera

A Coruña, Spain, 15006
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Hospital Universitario Puerta de Hierro Majadahonda

Majadahonda, Madrid, Spain, 28222
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ICO-Badalona Hospital Germans Trias i Pujol

Badalona, Barcelona, Spain, 08916
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Narodowy Instytut Onkologii im. Marii Skłodowskiej-Curie - Państwowy Instytut Badawczy

Warszawa, Poland, 02-781
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Szpital Kliniczny im. Heliodora Święcickiego UM w Poznaniu

Poznan, Poland, 60-780
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Clinica Viedma S. A

Viedma, RÍO Negro, Argentina, 8500
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Palmerston North Hospital

Palmerston North, Manawatu, New Zealand, 4414
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New Zealand Clinical Research (Christchurch)

Christchurch, Canterbury, New Zealand, 8011
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El Cielo Medical Center

Puebla, Mexico, 72160
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El Cielo Medical Center RSB, S.C

Puebla, Mexico, 72160
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I Can Oncology Center S.A. de C.V.

Monterrey, Nuevo LEÓN, Mexico, 64710
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Preparaciones Oncológicas S.C.

León, Guanajuato, Mexico, 37178
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Istituto Nazionale Tumori Regina Elena

Roma, Italy, 00144
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Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale"

Napoli, Italy, 80131
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Hospital Clinic Barcelona

Barcelona, Spain, 08036
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Istituto Europeo di Oncologia IRCCS

Milano, Italy, 20141
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CIUSSS du Saguenay-Lac-Saint-Jean

Chicoutimi, Quebec, Canada, G7H 5H6
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McGill University Health Centre - Glen Site

Montreal, Quebec, Canada, H4A 3J1
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Istituto di Candiolo IRCCS - Fondazione del Piemonte per l'Oncologia

Candiolo, Torino, Italy, 10060
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Fondazione IRCCS Istituto Nazionale dei Tumori

Milano, MI, Italy, 20133
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Jász-Nagykun-Szolnok Megyei Hetényi Géza Kórház

Szolnok, Hungary, 5004
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Szent-Gyorgyi Albert Klinikai Kozpont

Szeged, Hungary, 6720
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Debreceni Egyetem Klinikai Kozpont

Debrecen, Hungary, 4032
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Orszagos Onkologiai Intezet

Budapest, Hungary, 1122
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Semmelweis Egyetem

Budapest, Hungary, 1085
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Pécsi Tudományegyetem Klinikai Központ

Pécs, Baranya, Hungary, 7632
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Universitätsklinikum Essen (AöR)

Essen, Germany, 45147
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General Hospital of Athens "Laiko"

Athens, Attikí, Greece, 11527
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Hospital Universitari Vall D'Hebron, Servicio de Oncología Médica

Barcelona, Spain, 08035
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Drs Alberts, Bouwer and Jordaan Inc.

Pretoria, Gauteng, South Africa, 0081
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Hospital Universitario Reina Sofía

Cordoba, Spain, 14004
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University of Tennessee Medical Center

Knoxville, Tennessee, United States, 37920
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Derzhavna ustanova Instytut zahalnoi ta nevidkladnoi khirurhii im.V.T.Zaitseva Natsionalnoi akademii

M. Kharkiv, Ukraine, 61103
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Florida Cancer Specialists

Cape Coral, Florida, United States, 33909
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Florida Cancer Specialists

Fort Myers, Florida, United States, 33901
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AdventHealth Hematology and Oncology

Orlando, Florida, United States, 32804
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AdventHealth Orlando Infusion Center

Orlando, Florida, United States, 32804
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AdventHealth Orlando, Investigational Drug Services

Orlando, Florida, United States, 32804
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The University of Kansas Cancer Center

Westwood, Kansas, United States, 66205
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Hospital Universitario Virgen del Rocio

Sevilla, Spain, 41013
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Hospital Universitario Virgen Macarena

Sevilla, Spain, 41009
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St. Vincent Healthcare

Billings, Montana, United States, 59101
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St. Vincent Frontier Cancer Center

Billings, Montana, United States, 59102
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University of Cincinnati Medical Center

Cincinnati, Ohio, United States, 45219
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University of Cincinnati Medical Center

West Chester, Ohio, United States, 45069
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Fundacion Instituto Valenciano de Oncologia

Valencia, Spain, 46009
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Hospital Regional Universitario de Malaga - Hospital Civil

Málaga, Spain, 29011
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Sarah Cannon Research Institute

Nashville, Tennessee, United States, 37203
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Tennessee Oncology, PLLC

Nashville, Tennessee, United States, 37203
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Hospital Universitario Ramón y Cajal

Madrid, Spain, 28034
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Municipal Non-profit Enterprise "City Clinical Hospital #4" of Dnipro City Council

Dnipro, Ukraine, 49102
Not yet recruiting Get directions

Azienda Sanitaria Universitaria Friuli Centrale

Udine, Friuli Venezia Giulia, Italy, 33100
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Hospital Universitario Arnau de Vilanova

Lleida, Spain, 25198
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Medipol Mega Universite Hastanesi

İstanbul, İ̇stanbul, Turkey, 34214
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Ankara City Hospital

Ankara, Turkey, 06800
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Medical and diagnostic center of MedX-Ray International Group Limited Liability Company Israeli

Pliuty Village, KYIV Region, Obukhiv District, Ukraine, 08720
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Oslo universitetssykehus, Radiumhospitalet

Oslo, Norway, 0379
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Municipal non-profit enterprise Khmelnytsky regional antitumor center of Khmelnytsky regional

Khmelnytskyi, Ukraine, 29009
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Istituto Dermopatico dell'Immacolata (IDI-IRCCS)

Roma, RM, Italy, 00167
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Bioclinic Thessalonikis Private Clinic Single Member S.A.

Thessaloniki, Kentrikí Makedonía, Greece, 546 22
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University General Hospital of Heraklion

Heraklion, Irakleío, Greece, 71500
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Municipal non-profit enterprise "Kyiv City Clinical Hospital No. 2" of the executive body of the

Kyiv, Ukraine, 02094
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Metropolitan Hospital

Piraeus, Attikí, Greece, 185 47
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Complejo Hospitalario de Jaen

Jaen, Spain, 23007
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Hospital General Universitario Gregorio Marañón

Madrid, Spain, 28007
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Istituto Tumori Giovanni Paolo II

Bari, Italy, 70124
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A.O.U.S. Policlinico "Le Scotte"

Siena, SI, Italy, 53100
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Complejo Hospitalario De Navarra

Pamplona, Navarra, Spain, 31008
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Auckland City Hospital

Auckland, New Zealand, 1023
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Hospital Clinico Universitario Virgen de la Arrixaca

El Palmar, Murcia, Spain, 30120
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IRCCS Ospedale Policlinico San Martino

Genova, Italy, 16132
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UniversitätsSpital Zürich

Zürich Flughafen, Switzerland, 8058
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Hospital Universitario Marqués de Valdecilla

Santander, Cantabria, Spain, 39008
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Istituto Oncologico Veneto IOV - IRCCS

Padova, Italy, 35128
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Kantonsspital Winterthur

Winterthur, Switzerland, 8401
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Hospital de la Santa Creu i Sant Pau

Barcelona, Spain, 08041
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Fachklinik Hornheide

Münster, Germany, 48157
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BRCR Global Mexico - CDMX

Ciudad de México, Mexico, 01120
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Sandton Oncology Medical Group (Pty) Ltd

Johannesburg, Gauteng, South Africa, 2196
Not yet recruiting Get directions

POKO Poprad, s.r.o.

Poprad, Slovakia, 058 01
Not yet recruiting Get directions

Onkologicky ustav sv. Alzbety, s.r.o.

Bratislava, Slovakia, 812 50
Not yet recruiting Get directions

Klinikum Nürnberg Nord

Nürnberg, Germany, 90419
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UCLA - Hematology/Oncology - Administrative Office

Los Angeles, California, United States, 90024
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University Hospital Muenster

Muenster, Germany, 48149
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Baylor Clinic

Houston, Texas, United States, 77030
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Utah Cancer Specialists

Provo, Utah, United States, 84604
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Utah Cancer Specialists

Ogden, Utah, United States, 84405
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Utah Cancer Specialists

Murray, Utah, United States, 84157
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Utah Cancer Specialists

Layton, Utah, United States, 84041
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Utah Cancer Specialists

Bountiful, Utah, United States, 84010
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Utah Cancer Specialists

American Fork, Utah, United States, 84003
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Baylor Scott & White Medical Center - Temple

Temple, Texas, United States, 76508
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Texas Oncology-Paris

Paris, Texas, United States, 75460
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Dan Brown O.D.

Paris, Texas, United States, 75460
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Harris Health System - Smith Clinic

Houston, Texas, United States, 77054
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Harris Health System - Ben Taub Hospital

Houston, Texas, United States, 77030
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CHI St. Luke's Health Baylor College of Medicine Medical Center

Houston, Texas, United States, 77030
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Baylor College of Medicine

Houston, Texas, United States, 77030
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Baylor College of Medicine Medical Center

Houston, Texas, United States, 77030
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Texas Oncology - Flower Mound

Flower Mound, Texas, United States, 75028
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Utah Cancer Specialists

Salt Lake City, Utah, United States, 84106
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North Dallas Eye Associates

Flower Mound, Texas, United States, 75028
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Texas Oncology - Carrollton

Carrollton, Texas, United States, 75010
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Michigan Health Professionals

Farmington Hills, Michigan, United States, 48344
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Revive Research Institute, Inc.

Farmington Hills, Michigan, United States, 48334
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Ophthalmic Consultants of Boston Inc (OCB)

Boston, Massachusetts, United States, 02114
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Massachusetts General Hospital

Boston, Massachusetts, United States, 02114
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Advocate Medical Group-Park Ridge, Luther Lane-Oncology

Park Ridge, Illinois, United States, 60068
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University of Colorado Hospital - Anschutz Outpatient Pavilion (AOP)

Aurora, Colorado, United States, 80045
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University of Colorado Hospital - Anschutz Inpatient Pavilion (AIP)

Aurora, Colorado, United States, 80045
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University of Colorado Hospital - Anschutz Cancer Pavilion (ACP)

Aurora, Colorado, United States, 80045
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University of Colorado Denver CTO/CTRC

Aurora, Colorado, United States, 80045
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UCHealth Sue Anschutz-Rodgers Eye Center

Aurora, Colorado, United States, 80045
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UCLA Hematology/Oncology - Westwood (Building 100)

Los Angeles, California, United States, 90095
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Ronald Reagan UCLA Medical Center, Drug Information Center, Dept. of Pharmaceutical Services (Main O

Los Angeles, California, United States, 90095
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Utah Cancer Specialists

Salt Lake City, Utah, United States, 84102
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Utah Cancer Specialists

West Jordan, Utah, United States, 84088
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Universitätsklinikum Heidelberg

Heidelberg, Germany, 69120
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Fakultni nemocnice Olomouc

Olomouc, Olomoucký KRAJ, Czechia, 779 00
Not yet recruiting Get directions

Medizinische Hochschule Hannover

Hannover, Germany, 30625
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Universitaetsklinikum Halle - Universitaetsklinik und Poliklinik fuer Dermatologie und Venerologie

Halle, Germany, 06120
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Helios Klinikum Erfurt

Erfurt, Germany, 99089
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SRH Wald-Klinikum Gera

Gera, Thüringen, Germany, 07548
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Universitaetsklinikum Schleswig-Holstein Campus Kiel

Kiel, Schleswig-holstein, Germany, 24105
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Ronald Reagan UCLA Medical Center Drug Information Center , Dept. of Pharmaceutical Services (Drug

Los Angeles, California, United States, 90095
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Universitätsmedizin Johannes Gutenberg Universität Mainz

Mainz, Rheinland-pfalz, Germany, 55131
Not yet recruiting Get directions

Johannes Wesling Klinikum Minden

Minden, Nordrhein-westfalen, Germany, 32429
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Elbe Kliniken Stade-Buxtehude, Klinikum Buxtehude

Buxtehude, Niedersachsen, Germany, 21614
Not yet recruiting Get directions

Klinik und Poliklinik für Dermatologie und Allergologie

München, Bayern, Germany, 80337
Not yet recruiting Get directions

Universitaetsklinikum Erlangen

Erlangen, Bayern, Germany, 91054
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Helsinki University Hospital - Comprehensive Cancer Center (HYKS - Syöpäkeskus)

Helsinki, Finland, 00029
Not yet recruiting Get directions

Tampereen yliopistollinen sairaala

Tampere, Pirkanmaa, Finland, 33520
Not yet recruiting Get directions

Fakultni nemocnice Bulovka

Praha 8-Liben, Czechia, 180 81
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Saskatoon Cancer Center

Saskatoon, Saskatchewan, Canada, S7N4H4
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Utah Cancer Specialists

West Valley City, Utah, United States, 84119
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Kingston Health Sciences Centre-Kingston General Hospital Site

Kingston, Ontario, Canada, K7L 2V7
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Umhato Ead

Sofia, Bulgaria, 1756
Not yet recruiting Get directions

Acibadem City Clinic Multiprofile Hospital for Active Treatment Tokuda EAD

Sofia, Bulgaria, 1407
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Medical Center Nadezhda Clinical EOOD

Sofia, Bulgaria, 1373
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Complex Oncology Center-Ruse EOOD

Ruse, Bulgaria, 7002
Not yet recruiting Get directions

Complex Oncology Center - Plovdiv EOOD

Plovdiv, Bulgaria, 4004
Not yet recruiting Get directions

Hospital de Clinicas de Porto Alegre

Porto Alegre, RIO Grande DO SUL, Brazil, 90035-903
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VITAZ

Sint-Niklaas, Belgium, 9100
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Centre Hospitalier de Jolimont

Haine Saint Paul, Belgium, 7100
Not yet recruiting Get directions

Cliniques universitaires Saint-Luc

Brussels, Belgium, 1200
Not yet recruiting Get directions

AZ Sint-Jan Brugge-Oostende AV

Brugge, West-vlaanderen, Belgium, 8000
Not yet recruiting Get directions

UZ Brussel

Brussels, Bruxelles-capitale, Région DE, Belgium, 1090
Not yet recruiting Get directions

Instituto de Oncologia de Rosario

Rosario, Santa FE, Argentina, S2000KZE
Not yet recruiting Get directions

Instituto Alexander Fleming

Caba, Buenos Aires, Argentina, C1426ANZ
Not yet recruiting Get directions

Municipal non-profit enterprise "Zaporizhzhia Regional Antitumor Center" Zaporizhzhya Regional Counc

Zaporizhzhia, Ukraine, 69040
Not yet recruiting Get directions